ArticleBMC infectious diseases2019
Decreasing trends, and geographical variation in outpatient antibiotic use: a population-based study in Central Denmark.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Development of a checklist to support management of older patients withBMJ open quality · 2026Article
- Phenotypic-genotypic characteristics of Corynebacterium striatum clinical isolates and diversified biofilm production capabilities in the presence of plasma proteins.BMC microbiology · 2026Article
- Antibiotic Use and Risk of Microscopic Colitis in Older Adults: A Nationwide Self-Controlled Case Series Study.Alimentary pharmacology & therapeutics · 2025Article
- Inadequate empirical antibiotics following debridement for orthopedic infections do not increase therapy failures.Journal of bone and joint infection · 2025Article
- Use of antibiotics in early life and development of diseases in childhood: nationwide registry study.BMJ medicine · 2025Article
- Factors influencing antibiotic prescribing for respiratory tract infections in primary care - a comparison of physicians with different antibiotic prescribing rates.Scandinavian journal of primary health care · 2024Article
- Linking epidemiological and genomic data in cases of enteric fever in England to inform clinical management and public health action.The Journal of antimicrobial chemotherapy · 2024Article
- Trends in antibiotic prescribing in primary care out-of-hours doctors' services in Ireland.JAC-antimicrobial resistance · 2024Article
- Antimicrobial Sales Comparison before and after the Implementation of Nationwide Restriction Policy in Saudi Arabia.Antibiotics (Basel, Switzerland) · 2023Article
- Factors Associated with Geographical Variability of Antimicrobial Use in Japan.Infectious diseases and therapy · 2023Article
- Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy.PLOS digital health · 2023Article
- Antibiotic treatment of respiratory tract infections in adults in Norwegian general practice.JAC-antimicrobial resistance · 2023Article
- Ethical issues with geographical variations in the provision of health care services.BMC medical ethics · 2022Article
- Outpatient Antibiotic Use and Costs in Adults: A Nationwide Register-Based Study in Finland 2008-2019.Antibiotics (Basel, Switzerland) · 2022Article
- The Primary Care Perspective on the Norwegian National Strategy against Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2020Article
- Prevalence and Determinants of Antibiotic Consumption in the Elderly during 2006-2017.International journal of environmental research and public health · 2020Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntimicrobial overuse and misuse of broad-spectrum antibiotics increases the risk for antimicrobial resistance. Investigating unwarranted variation in antibiotic prescription has therefore gained global priority.
methodsWe examined recent time trends in the utilization of narrow- and broad-spectrum antibiotics as well as the variation in antibiotic use by sex, age, and municipality of residence. Complete individual-level data on all redeemed out-of hospital prescriptions for antibiotics in the entire adult population of Central Denmark (1.3 million inhabitants) was obtained for the period 2006-2015.
resultsFollowing an initial increase of 2% between 2006 and 2011, the overall rate of redeemed prescriptions for antibiotics per 1000 person years declined by 17% between 2011 and 2015. Among persons aged over 65 years, the decline in use began later (from 2013) and was less pronounced. Antibiotic use in 2015 remained substantially higher among females (289/1000 person-years) vs. males (182/1000 person-years) and among the very old (520/1000 person-years in >85y old) vs. middle-aged (204/1000 person-years in 45-65y old). A decreasing trend in antibiotic use over time was observed in all municipalities, mainly due to a decrease in narrow-spectrum antibiotics. However, a striking and unexplained 1.6-fold geographical variation in antibiotic use, including tetracyclines, macrolides and fluoroquinolones remained in 2015. Of concern, among females aged ≥65 years and males aged ≥85 years, a continuous increasing trend in broad-spectrum antibiotic use was observed.
conclusionsAntibiotic use has decreased almost 20% in Central Denmark after 2011, possibly related to a nationwide antibiotic stewardship program in Denmark. However, substantial geographical variation in antibiotic prescription remains and the use of broad-spectrum antibiotics has increased in adults of older age. Continuous focus on avoiding unnecessary use of broad-spectrum antibiotics is requested.
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