ArticleBMC infectious diseases2019
Nosocomial bloodstream infection and the emerging carbapenem-resistant pathogen Ralstonia insidiosa.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Epidemiological and genomic characteristics ofMicrobiology spectrum · 2025Article
- Investigation of co-existing bacteria in platelets by employing long-term culturomics and metagenomics.Frontiers in cellular and infection microbiology · 2025Article
- An Analysis of the Etiology and Treatment of Ralstonia pickettii Bloodstream Infection in 2 Critically Ill Patients: A Case Report Highlighting an Emerging Pediatric Pathogen.Clinical medicine insights. Pediatrics · 2025Article
- NovelMicrobiology spectrum · 2024Article
- Molecular epidemiological and clinical infection characteristics analysis of Ralstonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- The Dynamic Changes ofPlants (Basel, Switzerland) · 2024Article
- Development of antibody to virulence factor flagellin and its evaluation in screening Ralstonia pseudosolanacearum.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Case report: special imaging features in a uremic patient with intracranial infection caused byFrontiers in medicine · 2024Article
- Differential effects of wastewater treatment plant effluents on the antibiotic resistomes of diverse river habitats.The ISME journal · 2023Article
- Bioinformatic Analysis Reveals the Role of Translation Elongation Efficiency Optimisation in the Evolution ofBiology · 2023Article
- A case of meningitis caused by Ralstonia insidiosa, a rare opportunistic pathogen.BMC infectious diseases · 2023Review
- Clinical Manifestation ofJournal of Korean medical science · 2023Article
- Children with infectious pneumonia caused byWorld journal of clinical cases · 2023Article
- Concomitant analyses of intratumoral microbiota and genomic features reveal distinct racial differences in breast cancer.NPJ breast cancer · 2023Article
- Transcriptomic and metabolomic analyses to study the key role by whichFrontiers in microbiology · 2023Article
- Elucidating the roles of the mammary and gut microbiomes in breast cancer development.Frontiers in oncology · 2023Review
- Nasopharyngeal microbiome of COVID-19 patients revealed a distinct bacterial profile in deceased and recovered individuals.Microbial pathogenesis · 2022Article
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- Polystyrene microplastics induce gut microbiome and metabolome changes in Javanese medaka fish (Toxicology reports · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRalstonia picketti, Ralstonia mannitolilytica, and Ralstonia insidiosa have recently been regarded as emerging pathogens of infectious diseases, in particular as the pathogens responsible for nosocomial infection in immunocompromised patients. R. insidiosa differs from R. picketti and R. mannitolilytica, and its related infections are rarely reported.
methodsClinical data from two nosocomial bloodstream infection cases were extracted and analyzed. The causable isolates were identified by the VITEK 2 Compact system, matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and molecular identification methods using PCR with universal and species-specific primers. Antimicrobial susceptibility testing was performed using the broth microdilution method. Both of the isolates were subjected to whole genome sequencing using a HiSeq X10 Sequencer. Antimicrobial resistance genes, virulence factors, and plasmid replicons were identified from assembled genomes. A real-time RT-PCR experiment and a cloning experiment were conducted to explore the related class D β-lactamase-encoding genes.
resultsBoth patients recovered under therapy with antibiotics. Isolates were initially misidentified as R. mannitolilytica by the VITEK 2 Compact system rather than R. insidiosa, as identified by both MALDI-TOF MS and 16S rRNA gene sequencing. Both isolates were resistant to aminoglycosides, β-lactams, and polymyxin B. One isolate harboring bla
conclusionsWe described two cases of nosocomial bloodstream infection caused by R. insidiosa strains. MALDI-TOF MS was cost-effective for rapid species identification. Clinicians should be aware that R. insidiosa can be resistant to commonly used antibiotics, even carbapenems.
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