ArticleBMC infectious diseases2019
Seroepidemiology of dengue virus infection among adults during the ending phase of a severe dengue epidemic in southern Taiwan, 2015.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- Ten-year trend and geographic analysis of the incidence of dengue in Taiwan.IJID regions · 2025Article
- Estimating the force of infection of four dengue serotypes from serological studies in two regions of Vietnam.PLoS neglected tropical diseases · 2024Article
- Risks of anxiety disorders, depressive disorders, and sleep disorders in patients with dengue fever: A nationwide, population-based cohort study.PLoS neglected tropical diseases · 2024Article
- Substantial discrepancies in dengue case estimates between the Global Burden of Disease Study and Taiwan Centers for Disease Control.Journal of travel medicine · 2024Article
- Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study.PLoS neglected tropical diseases · 2023Article
- Risks of Acute Cholecystitis, Acute Pancreatitis, and Acute Appendicitis in Patients with Dengue Fever: A Population-Based Cohort Study in Taiwan.Infectious diseases and therapy · 2023Article
- Development and Utility of Practical Indicators of Critical Outcomes in Dengue Patients Presenting to Hospital: A Retrospective Cross-Sectional Study.Tropical medicine and infectious disease · 2023Article
- Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study.PLoS neglected tropical diseases · 2023Article
- A case-control study to determine the risk factors of dengue fever in Chattogram, Bangladesh.Public health in practice (Oxford, England) · 2022Article
- Epidemiology of Indigenous Dengue Cases in Zhejiang Province, Southeast China.Frontiers in public health · 2022Article
- Short-term, medium-term, and long-term risks of nonvariceal upper gastrointestinal bleeding after dengue virus infection.PLoS neglected tropical diseases · 2022Article
- Article
- Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country.PLoS neglected tropical diseases · 2021Article
- Retrospective Seroepidemiology study of dengue virus infection in Taiwan.BMC infectious diseases · 2021Article
- Use of Animal Models in Studying Roles of Antibodies and Their Secretion Cells in Dengue Vaccine Development.Viruses · 2020Review
- Low seroprevalence of Zika virus infection among adults in Southern Taiwan.BMC infectious diseases · 2019Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA severe dengue epidemic occurred in 2015 which resulted in over 22,000 laboratory-confirmed cases. A cross-sectional seroprevalence study was conducted during the ending phase of this epidemic to evaluate the true incidence of dengue virus (DENV) infection and the level of herd immunity.
methodsAdult residents in three administrative districts with high dengue incidence were recruited; workers in two districts with intermediate dengue incidence were also recruited for comparison. DENV-specific IgM and IgG were tested using commercial enzyme-linked immunosorbent assays. DENV RNA was detected using commercial quantitative real-time reverse transcriptase polymerase chain reaction assay. Univariate and multivariate logistic regressions were performed to identify risk factors for recent and past DENV infection.
resultsThe overall seroprevalence of anti-DENV IgM and IgG in 1391 participants was 6.8 and 17.4%, respectively. The risk of recent DENV infection increased with age, with the elderly having the highest risk of infection. Living in areas with high incidence of reported dengue cases and having family members being diagnosed with dengue in 2015 were also independent risk factors for recent DENV infection. One sample was found to have asymptomatic viremia with viral load as high as 10
conclusionsComparing the seroprevalence of anti-DENV IgM with the incidence of reported dengue cases in 2015, we estimated that 1 out of 3.7 dengue infections were reported to the surveillance system; widespread use of rapid diagnostic tests might contribute to this high reporting rate. The results also indicate that the overall herd immunity remains low and the current approved Dengvaxia® is not quite suitable for vaccination in Taiwan.
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