ArticleRenal failure2019
The incidence of acute kidney injury following cardiac arrest and cardiopulmonary resuscitation in a rat model.
Article in Renal failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 13 citations in OpenAlex.
- Intravoxel incoherent motion MRI for early detection and assessment of renal injury after cardiac arrest and resuscitation in a rat model.European radiology experimental · 2026Article
- The role of (Diagnostic and interventional radiology (Ankara, Turkey) · 2023Article
- Review
- The Influence of Ultra-Low Tidal Volume Ventilation during Cardiopulmonary Resuscitation on Renal and Hepatic End-Organ Damage in a Porcine Model.Biomedicines · 2023Article
- Bio-physiological susceptibility of the brain, heart, and lungs to systemic ischemia reperfusion and hyperoxia-induced injury in post-cardiac arrest rats.Scientific reports · 2023Article
- Changes of antioxidant enzymes in the kidney after cardiac arrest in the rat model.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms.Journal of clinical medicine · 2022Review
- Prognostic significance of the blood urea nitrogen to creatinine ratio in in-hospital cardiac arrest after targeted temperature management.Journal of the Chinese Medical Association : JCMA · 2022Article
- Renal Injuries after Cardiac Arrest: A Morphological Ultrastructural Study.International journal of molecular sciences · 2022Article
- Levosimendan in rats decreases acute kidney injury after cardiopulmonary resuscitation by improving mitochondrial dysfunction.Translational andrology and urology · 2021Article
- Estrogen and estrogen receptors in kidney diseases.Renal failure · 2021Review
- Changes of renal histopathology and the role of Nrf2/HO-1 in asphyxial cardiac arrest model in rats.Acta cirurgica brasileira · 2021Article
- Review
- Association between acute kidney injury and mortality after successful cardiopulmonary resuscitation: a retrospective observational study.Brazilian journal of anesthesiology (Elsevier)Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the current study, we investigated the incidence of acute kidney injury (AKI) induced by cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) and whether such an AKI can recover spontaneously in rats.
methodsWe used transesophageal alternating current stimulation to establish 7 min of CA rat model followed by conventional CPR. The experimental rats were randomly divided into three groups (n = 20 per group) according to the different time points after restoration spontaneous circulation (ROSC): the ROSC 24 h, ROSC 48 h, and ROSC 72 h group. The diagnosis of rat AKI refers to the 2012 KDIGO adult AKI diagnostic criteria. The severity of AKI quantified by the serum creatinine (SCR), blood urea nitrogen (BUN) levels and histological features of renal tissue.
resultsThe incidence rates of AKI in ROSC 24 h, ROSC 48 h, and ROSC 72 h group were 65%, 45%, and 42.9%. Moreover, the values of SCR and BUN were highest at ROSC 24 h, and then gradually decreased with the time of ROSC. The histological changes of the renal tissues such as glomerular collapse, renal tubular cell swelling, and inflammatory cell infiltration had also observed.
conclusionThe incidence of AKI in rats was high after suffering from CA and CPR, but renal function improved with the prolongation of ROSC time, indicating the ability of the kidney to self-repair.
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