Evidence map›Paper›PMID 31013990›Full record

ArticleInternational journal of molecular sciences2019

DNA Methylation Contributes to the Differential Expression Levels of

Vichithra R B Liyanage, Carl O Olson, Robby M Zachariah, James R Davie, Mojgan Rastegar

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. The Chromatin Structure at theInternational journal of molecular sciences · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Transcriptional Regulation ofBiomolecules · 2021
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. The MeCP2E1/E2-BDNF-Frontiers in cell and developmental biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vichithra R B LiyanageRegenerative Medicine Program, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. jim.davie@umanitoba.ca.
Carl O OlsonRegenerative Medicine Program, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. carl.olson@umanitoba.ca.
Robby M ZachariahRegenerative Medicine Program, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. robbymz@gmail.com.
James R DavieDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. jim.davie@umanitoba.ca.
Mojgan RastegarRegenerative Medicine Program, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. mojgan.rastegar@umanitoba.ca.ORCID 0000-0003-3619-6116
University of Manitoba · CA

Funding

Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant 2016-06035 to MR, International Rett Syndrome Foundation (IRSF) grant #3212 to MR, and Ontario Rett Syndrome Association to MR IRSF 3212, NSERC-DG2016-06035
6 · The paper itself

Abstract

Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT),

Indexed as

DNA MethylationAnimalsAstrocytesBrainCells, CulturedCpG IslandsDisease Models, AnimalFemaleGenes, X-LinkedMaleMethyl-CpG-Binding Protein 2MiceNeurodevelopmental DisordersNeuronsProtein IsoformsMethyl-CpG-Binding Protein 2Protein Isoformsastrocytesbrain cellsDNA methylationepigeneticsMeCP2 isoformsneurodevelopmental disordersneuronsRett syndrome

Identifiers

PMID31013990
PMCPMC6514911
OpenAlexW2937950541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.