Evidence map›Paper›PMID 31013923›Full record

ReviewNutrients2019

β-carotene in Obesity Research: Technical Considerations and Current Status of the Field.

Johana Coronel, Ivan Pinos, Jaume Amengual

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Immunometabolic effects ofImmunometabolism (Cobham, Surrey) · 2024
    Review
  11. Observational
  12. Article
  13. β-carotene accelerates the resolution of atherosclerosis in mice.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Johana CoronelDepartment of Food Sciences and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL 61801, USA. acoronel@illinois.edu.
Ivan PinosDivision of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL 61801, USA. ivanp2@illinois.edu.ORCID 0000-0002-2236-8936
Jaume AmengualDepartment of Food Sciences and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL 61801, USA. jaume6@illinois.edu.
University of Illinois Urbana-Champaign · US

Funding

To study the role of the low-density lipoprotein receptor on carotenoid biodistribution and excretionR01HL147252 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI AMENGUAL TERRASA, JAIME · 2019 to 2023
$2.1M
American Heart Association 16SDG27550012NHLBI NIH HHS R01 HL147252U.S. Department of Agriculture W4002
6 · The paper itself

Abstract

Over the past decades, obesity has become a rising health problem as the accessibility to high calorie, low nutritional value food has increased. Research shows that some bioactive components in fruits and vegetables, such as carotenoids, could contribute to the prevention and treatment of obesity. Some of these carotenoids are responsible for vitamin A production, a hormone-like vitamin with pleiotropic effects in mammals. Among these effects, vitamin A is a potent regulator of adipose tissue development, and is therefore important for obesity. This review focuses on the role of the provitamin A carotenoid β-carotene in human health, emphasizing the mechanisms by which this compound and its derivatives regulate adipocyte biology. It also discusses the physiological relevance of carotenoid accumulation, the implication of the carotenoid-cleaving enzymes, and the technical difficulties and considerations researchers must take when working with these bioactive molecules. Thanks to the broad spectrum of functions carotenoids have in modern nutrition and health, it is necessary to understand their benefits regarding to metabolic diseases such as obesity in order to evaluate their applicability to the medical and pharmaceutical fields.

Indexed as

AdipocytesAnimalsbeta Carotenebeta-Carotene 15,15'-MonooxygenaseDietHumansObesitybeta Carotenebeta-Carotene 15,15'-MonooxygenaseadipocyteVitamin Aβ-carotene oxygenase 1

Identifiers

PMID31013923
PMCPMC6521044
OpenAlexW2936260138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.