Evidence map›Paper›PMID 31013608›Full record

ArticleInternational journal of molecular sciences2019

Construction of Dimeric Drug-Loaded Polymeric Micelles with High Loading Efficiency for Cancer Therapy.

Bing Yu, Qingye Meng, Hao Hu, Tao Xu, Youqing Shen, Hailin Cong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bing YuInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. yubingqdu@163.com.
Qingye MengInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. mengqingye94@163.com.
Hao HuInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. huhao@qdu.edu.cn.
Tao XuInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. 15165520337@126.com.
Youqing ShenInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. amnano@163.com.
Hailin CongInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China. conghailin@qdu.edu.cn.ORCID 0000-0001-9044-1376

Funding

Innovation Leader Project of Qingdao 168325zhcKey Research and Development Project of Shandong Province 2016GGX102028Key Research and Development Project of Shandong Province 2016GGX102039Key Research and Development Project of Shandong Province 2017GGX20111Major Science and Technology Innovation Project of Shandong Province 2018CXGC1407National Natural Science Foundation of China 21574072National Natural Science Foundation of China 21675091National Natural Science Foundation of China 21874078National Natural Science Foundation of China 51703105Natural Science Foundation of Shandong Province ZR2017BEM012People's Livelihood Science and Technology Project of Qingdao 166257nshPeople's Livelihood Science and Technology Project of Qingdao 173378nshProject of Shandong Province Higher Educational Science and Technology Program J15LC20Taishan Young Scholar Program of Shandong Province tsqn20161027
6 · The paper itself

Abstract

Polymeric micelles (PMs) have been applied widely to transport hydrophobic drugs to tumor sites for cancer treatment. However, the low load efficiency of the drug in the PMs significantly reduces the therapeutic efficiency. We report here that disulfide-linked camptothecin (CPT) as a kind of dimeric drug can be effectively embedded in the core of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) PMs for improving drug-loading efficiency, and PEG can be used as a hydrophilic shell. Moreover, the dimeric CPT-loaded PCL-PEG-PCL PMs exhibited excellent solubility in phosphate-buffered saline (PBS) media and significant cytotoxicity to cancer cells.

Indexed as

Drug CarriersMicellesPolymersAnimalsAntineoplastic AgentsCell LineHumansMicePolyestersPolyethylene GlycolsSpectrum AnalysisAntineoplastic AgentsDrug CarriersMicellespoly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone)PolyestersPolyethylene GlycolsPolymerscamptothecincancer therapydimeric drugmicelles

Identifiers

PMID31013608
PMCPMC6515377

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.