Evidence map›Paper›PMID 31013590›Full record

ReviewPathogens (Basel, Switzerland)2019

Spyridoula-Angeliki Nikou, Nessim Kichik, Rhys Brown, Nicole O Ponde, Jemima Ho, Julian R Naglik, Jonathan P Richardson

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Network Pharmacology-Guided Identification ofInternational journal of molecular sciences · 2026
    Article
  8. Probiotic and Postbiotic Interactions ofAntibiotics (Basel, Switzerland) · 2026
    Article
  9. mBio · 2026
    Article
  10. Article
  11. Molecular mechanisms, pathogenesis and therapeutic advances ofFrontiers in cellular and infection microbiology · 2026
    Review
  12. Review
  13. mSphere · 2025
    Article
  14. Review
  15. Article
  16. Anti-adhesive glycoconjugates againstFuture medicinal chemistry · 2025
    Article
  17. Review
  18. Synergistic effects ofFrontiers in cellular and infection microbiology · 2025
    Article
  19. Fluconazole tolerance and virulence adaptations ofJournal of oral microbiology · 2025
    Article
  20. Modulation ofMicroorganisms · 2024
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Spyridoula-Angeliki NikouProtein Phosphorylation Laboratory, The Francis Crick Institute, London NW1 1AT, UK. spyridoula.nikou@crick.ac.uk.
Nessim KichikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 1UL, UK. nessim.kichik@kcl.ac.uk.
Rhys BrownCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 1UL, UK. rhys.brown@kcl.ac.uk.
Nicole O PondeCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 1UL, UK. nicole.ponde@kcl.ac.uk.
Jemima HoCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 1UL, UK. jemima.ho@kcl.ac.uk.
Julian R NaglikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 1UL, UK. julian.naglik@kcl.ac.uk.
Jonathan P RichardsonCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 1UL, UK. jonathan.richardson@kcl.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/N014677/1Biotechnology & Biological Sciences Research Council BB/N014677/1King's Health Partners Challenge Fund R170501Medical Research Council MC_PC_16048NIH HHS R37-DE022550The NIH Research at Guys and St. Thomas's NHS Foundation Trust and the King's College London Biomedical Research Centre IS-BRC-1215-20006The Rosetrees Trust M680
6 · The paper itself

Abstract

Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C. albicans with a mucosal surface is an essential prerequisite for fungal colonisation and epitomises the complex interface between microbe and host. C. albicans exhibits numerous adaptations to a healthy host that permit commensal colonisation of mucosal surfaces without provoking an overt immune response that may lead to clearance. Conversely, fungal adaptation to impaired immune fitness at mucosal surfaces enables pathogenic infiltration into underlying tissues, often with devastating consequences. This review will summarise our current understanding of the complex interactions that occur between C. albicans and the mucosal surfaces of the human body.

Indexed as

Candida albicanscommensalfungusmicrobiotamucosal infectionpathogen

Identifiers

PMID31013590
PMCPMC6631630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.