ArticleThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2019
The Clinical Significance of Microsatellite Instability in Patients with Right-sided Colorectal Cancer.
Article in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- Prognostic and Treatment-Associated Survival Effects of Microsatellite Instability Across Disease Stages in Colon Cancer: An NCDB Analysis.Journal of gastrointestinal cancer · 2026Article
- Article
- [Clinicopathological features and types of microsatellite instability in 1394 patients with colorectal cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer.Journal of translational medicine · 2019Article
- Surgery Reduces Cancer-specific Death in Elderly Right-Sided Colon Cancer: A SEER-Based Competing-Risk Analysis.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsColorectal cancer (CRC) with microsatellite instability (MSI) has a better prognosis than CRC with microsatellite stable (MSS). Recent studies have reported biological differences according to tumor location in CRC. In this study, we investigated the clinical significance of MSI in patients with right-sided CRC.
methodsThe medical records of 1,009 CRC patients diagnosed at our institute between October 2004 and December 2016 with MSI test results were retrospectively reviewed. The long-term outcomes of CRC patients with MSI were assessed with respect to tumor location using Kaplan-Meier curves and Cox regression models.
resultsThe median follow-up duration for all 1,009 study subjects was 25 months (interquartile range, 15-38). One hundred twenty-four of the study subjects had MSI (12.3%) and 250 had right-sided CRC (24.8%). The patients with MSI and right-sided CRC had better disease-free survival (DFS) than those with MSS as determined by the log-rank test (p=0.013), and this result was significant in females (p=0.035) but not in males with right-sided CRC. Multivariate Cox regression analysis showed MSS significantly predicted poor DFS in patients with right-sided CRC (hazard ratio 3.97, 95% CI 1.30-12.15, p=0.016) and in female patients (hazard ratio 4.69, 95% CI 1.03-21.36, p=0.045).
conclusionsThe study shows MSI is a useful predictor of DFS in patients with right-sided CRC, especially in female patients.
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