Evidence map›Paper›PMID 31013507›Full record

ArticleNeuro-degenerative diseases2019

Physician and Surrogate Agreement with Assisted Dying and Continuous Deep Sedation in Advanced Dementia in Switzerland.

Andrea Jutta Loizeau, Simon M Cohen, Susan L Mitchell, Nathan Theill, Stefanie Eicher, Mike Martin, Florian Riese

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Neuro-degenerative diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Andrea Jutta LoizeauUniversity Research Priority Program "Dynamics of Healthy Aging," University of Zurich, Zurich, Switzerland, AndreaLoizeau@hsl.harvard.edu.
Simon M CohenHebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts, USA.
Susan L MitchellHebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts, USA.
Nathan TheillUniversity Research Priority Program "Dynamics of Healthy Aging," University of Zurich, Zurich, Switzerland.
Stefanie EicherUniversity Research Priority Program "Dynamics of Healthy Aging," University of Zurich, Zurich, Switzerland.
Mike MartinUniversity Research Priority Program "Dynamics of Healthy Aging," University of Zurich, Zurich, Switzerland.
Florian RieseUniversity Research Priority Program "Dynamics of Healthy Aging," University of Zurich, Zurich, Switzerland.
University of Zurich · CHHebrew SeniorLife · US

Funding

An RCT of an Educational Video to Improve Nursing Home Care in End-Stage DementiaR01AG043440 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MITCHELL, SUSAN L, VOLANDES, ANGELO · 2012 to 2016
$3.2M
Determinants, Decision-Making and Outcomes of Antibiotic Use in Advanced DementiaR01AG032982 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI D'AGATA, ERIKA M, MITCHELL, SUSAN L · 2009 to 2013
$2.9M
Midcareer Mentoring Award for Patient-Oriented Research in AgingK24AG033640 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MITCHELL, SUSAN L · 2009 to 2018
$1.8M
NIA NIH HHS K24 AG033640NIA NIH HHS R01 AG032982NIA NIH HHS R01 AG043440
6 · The paper itself

Abstract

backgroundAssisted dying and continuous deep sedation (CDS) are controversial practices. Little is known about the perceptions of physicians and surrogates about these practices for patients with advanced dementia.

objectivesTo describe and compare physician and surrogate agreement with the use of assisted dying and CDS in advanced dementia. DESIGN, SETTING, SUBJECTS: Physicians (n = 64) and surrogates (n = 168) of persons with advanced dementia were recruited as part of a randomized controlled trial in Switzerland that tested decision support tools in this population.

methodsAt baseline, the participants were asked about their agreement with assisted dying and CDS in advanced dementia using the following response options: "completely agree," "somewhat agree," "somewhat disagree," "completely disagree," and "do not know." Multivariable logistic regressions compared the likelihood that surrogates versus physicians would completely or somewhat agree (vs. completely or somewhat disagree) with these practices.

resultsThe physicians and surrogates, respectively, had a mean age (SD) of 50.6 years (9.9) and 57.4 years (14.6); 46.9% (n = 30/64) and 68.9% (n = 115/167) were women. A total of 20.3% (n = 13/64) of the physicians and 47.0% (n = 79/168) of the surrogates agreed with assisted dying in advanced dementia. Surrogates were significantly more likely to agree with this practice than physicians (adjusted odds ratio, 3.87; 95% CI: 1.94, 7.69). With regard to CDS, 51.6% (n = 33/64) of the physicians and 41.9% (n = 70/169) of the surrogates agreed with this practice, which did not differ significantly between the groups.

conclusionsThe surrogates were more agreeable to considering assisted dying in the setting of advanced dementia than the physicians, and about half of the participants in both groups reported CDS to be an appropriate option for this population.

Indexed as

AdultAgedAttitude of Health PersonnelAttitude to DeathAttitude to HealthDecision Support TechniquesDeep SedationDementiaEuthanasiaFamilyFemaleHumansLegal GuardiansMaleMiddle AgedPhysiciansAssisted dyingDecision-makingDementiaEnd of lifeSedation

Identifiers

PMID31013507
PMCPMC6692213
OpenAlexW2941869281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.