ArticlePloS one2019
Comparison of the microbiome, metabolome, and lipidome of obese and non-obese horses.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- A novel dataset of 2,362 equine fecal microbiomes from veterinary teaching hospitals across three countries reveals effects of geography and disease.Animal microbiome · 2025Article
- Bile acids segregate metabolic syndrome in a cohort of 100 deeply phenotyped horses.Communications biology · 2025Article
- Faecal microbiota and serum metabolome association with equine metabolic syndrome in connemara ponies.BMC veterinary research · 2025Article
- Remodeling of intestinal bacterial community and metabolome of Dezhou donkey induced by corn silage.Scientific reports · 2024Article
- Lipids in Equine Airway Inflammation: An Overview of Current Knowledge.Animals : an open access journal from MDPI · 2024Review
- Current Understanding of Equine Gut Dysbiosis and Microbiota Manipulation Techniques: Comparison with Current Knowledge in Other Species.Animals : an open access journal from MDPI · 2024Review
- Effect of Exercise Conditioning on Countering the Effects of Obesity and Insulin Resistance in Horses-A Review.Animals : an open access journal from MDPI · 2024Review
- Metabolic and Endocrine Insights in Donkeys.Animals : an open access journal from MDPI · 2024Review
- Lipid species profiling of bronchoalveolar lavage fluid cells of horses housed on two different bedding materials.Scientific reports · 2023Article
- Effects of Concentrate Feeding Sequence on Growth Performance, Nutrient Digestibility, VFA Production, and Fecal Microbiota of Weaned Donkeys.Animals : an open access journal from MDPI · 2023Article
- Gastro-Intestinal Microbiota in Equines and Its Role in Health and Disease: The Black Box Opens.Microorganisms · 2022Review
- Gut Microbiome Characteristics in feral and domesticated horses from different geographic locations.Communications biology · 2022Article
- The effects ofFrontiers in microbiology · 2022Article
- Metabolic profile distinguishes laminitis-susceptible and -resistant ponies before and after feeding a high sugar diet.BMC veterinary research · 2021Article
- Effect of host breeds on gut microbiome and serum metabolome in meat rabbits.BMC veterinary research · 2021Article
- A Multiomic Approach to Investigate the Effects of a Weight Loss Program on the Intestinal Health of Overweight Horses.Frontiers in veterinary science · 2021Article
- Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome.Frontiers in veterinary science · 2021Article
- Article
- The cecal and fecal microbiomes and metabolomes of horses before and after metronidazole administration.PloS one · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic diseases such as obesity and type 2 diabetes in humans have been linked to alterations in the gastrointestinal microbiota and metabolome. Knowledge of these associations has improved our understanding of the pathophysiology of these diseases and guided development of diagnostic biomarkers and therapeutic interventions. The cellular and molecular pathophysiology of equine metabolic syndrome (EMS) and obesity in horses, however, remain ill-defined. Thus, the objectives of this study were to characterize the fecal microbiome, fecal metabolome, and circulating lipidome in obese and non-obese horses. The fecal microbiota, fecal metabolome, and serum lipidome were evaluated in obese (case) horses (n = 20) and non-obese (control) horses (n = 20) matched by farm of origin (n = 7). Significant differences in metabolites of the mitochondrial tricarboxylic acid cycle and circulating free fatty acids were identified in the obese horses compared to the non-obese horses. These results indicate that the host and bacterial metabolism should be considered important in obese horses. Further studies to determine whether these associations are causal and the mechanistic basis of the association are warranted because they might reveal diagnostic biomarkers and therapeutic interventions to mitigate obesity, EMS, and sequelae including laminitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.