ArticlePloS one2019
Natural variation in the roles of C. elegans autophagy components during microsporidia infection.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Microsporidia: evolution, infection mechanisms and host impact.Nature reviews. Microbiology · 2026Review
- Defense against parasites covaries with reproductive timing, not with resistance.PLoS pathogens · 2026Article
- Parasite defense covaries with reproductive timing, not with resistance.bioRxiv : the preprint server for biology · 2026Article
- Intersections between proteostasis and immunity: insights from Caenorhabditis elegans.Disease models & mechanisms · 2026Review
- Condition-dependent effects of knockdown of autophagy onbioRxiv : the preprint server for biology · 2025Article
- Article
- High temperatures and low humidity promote the occurrence of microsporidians (Microsporidia) in mosquitoes (Culicidae).Parasites & vectors · 2024Article
- High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits.PLoS pathogens · 2023Article
- RNA Fluorescence in situ Hybridization (FISH) to Visualize Microbial Colonization and Infection in Caenorhabditis elegans Intestines.Journal of visualized experiments : JoVE · 2022Article
- Contrasting parasite-mediated reductions in fitness within versus between patches of a nematode host.Evolution; international journal of organic evolution · 2022Article
- The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans.Nature communications · 2022Article
- Article
- Nosema apis and N. ceranae Infection in Honey bees: A Model for Host-Pathogen Interactions in Insects.Experientia supplementum (2012) · 2022Article
- Phagocytosis Is the Sole Arm ofFrontiers in immunology · 2022Article
- Insights from C. elegans into Microsporidia Biology and Host-Pathogen Relationships.Experientia supplementum (2012) · 2022Review
- Factors That Determine Microsporidia Infection and Host Specificity.Experientia supplementum (2012) · 2022Review
- A parental transcriptional response to microsporidia infection induces inherited immunity in offspring.Science advances · 2021Article
- Ubiquitin-related processes and innate immunity in C. elegans.Cellular and molecular life sciences : CMLS · 2021Review
- Genetic Variation inMicroorganisms · 2020Review
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Natural genetic variation can determine the outcome of an infection, and often reflects the co-evolutionary battle between hosts and pathogens. We previously found that a natural variant of the nematode Caenorhabditis elegans from Hawaii (HW) has increased resistance against natural microsporidian pathogens in the Nematocida genus, when compared to the standard laboratory strain of N2. In particular, HW animals can clear infection, while N2 animals cannot. In addition, HW animals have lower levels of initial colonization of Nematocida inside intestinal cells, compared to N2. Here we investigate how this natural variation in resistance relates to autophagy. We found that there is much better targeting of autophagy-related machinery to parasites under conditions where they are cleared. In particular, ubiquitin targeting to Nematocida cells correlates very well with their subsequent clearance in terms of timing, host strain and age, as well as species of Nematocida. Furthermore, clearance correlates with targeting of the LGG-2/LC3 autophagy protein to parasite cells, with HW animals having much more efficient targeting of LGG-2 to parasite cells than N2 animals. Surprisingly, however, we found that LGG-2 is not required to clear infection. Instead, we found that LGG-2/LC3 regulates Nematocida colonization inside intestinal cells. Interestingly, LGG-2/LC3 regulates intracellular colonization only in the HW strain, and not in N2. Altogether these results demonstrate that there is natural genetic variation in an LGG-2-dependent process that regulates microsporidia colonization inside intestinal cells, although not microsporidia clearance.
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