Evidence map›Paper›PMID 31012816›Full record

ArticleRadiology2019

Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden.

Zixuan Lin, Sandeepa Sur, Anja Soldan, Corinne Pettigrew, Michael Miller, Kenichi Oishi, Murat Bilgel, Abhay Moghekar, Jay J Pillai, Marilyn Albert and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  10. Article
  11. Review
  12. Biomarkers of aging.Science China. Life sciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zixuan LinFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).ORCID 0000-0001-9462-7768
Sandeepa SurFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).ORCID 0000-0001-6471-7578
Anja SoldanFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).ORCID 0000-0002-6193-0418
Corinne PettigrewFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).
Michael MillerFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).ORCID 0000-0003-4689-3855
Kenichi OishiFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).ORCID 0000-0002-1200-8611
Murat BilgelFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).
Abhay MoghekarFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).
Jay J PillaiFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).
Marilyn AlbertFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).
Hanzhang LuFrom the Department of Biomedical Engineering (Z.L., M.M., H.L.), The Russell H. Morgan Department of Radiology and Radiological Science (Z.L., S.S., K.O., J.J.P., H.L.), and Department of Neurology (A.S., C.P., A.M., M.A.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Park 322, Baltimore, Md; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Md (M.B.); and F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Md (H.L.).ORCID 0000-0003-3871-1564
Johns Hopkins University · USKennedy Krieger Institute · USNational Institutes of Health · US

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2014 to 2026
$51.5M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3M
Early imaging markers for elderly individuals with high risk to develop Alzheimer's diseaseR21AG055153 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2016 to 2017
$449k
Intramural NIH HHS Z99 AG999999NIA NIH HHS P30 AG066507NIA NIH HHS R21 AG055153NIA NIH HHS U19 AG033655
6 · The paper itself

Abstract

Background Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset Alzheimer disease. However, the mechanisms by which APOE4 affects the brain, underpinning this risk, have not been fully elucidated. Purpose To investigate the influence of APOE4 on global cerebral oxygen extraction fraction (OEF) and possible mediation through amyloid burden by using MRI-based brain oxygen extraction technique. Materials and Methods Participants were enrolled from a longitudinal prospective study, the Biomarkers for Older Controls at Risk for Dementia study (data collected from January 2015 to December 2017), of whom 35% (50 of 143 participants) were APOE4 carriers. OEF was measured by using a T2-relaxation-under-spin-tagging MRI technique with a 3.0-T MRI system. PET acquired with carbon 11-labeled Pittsburgh compound B tracer was available in 119 participants to measure amyloid burden. Cognitive performance was assessed by using domain-specific composite scores including executive function, episodic memory, visual-spatial processing, and language. Linear regression analysis was performed to investigate the relationship between APOE4, OEF, and amyloid burden. The association between OEF and cognitive function was studied for the entire study cohort and separately for the APOE4 carriers and noncarriers. Results A total of 143 cognitively healthy individuals (mean age 6 standard deviation, 69.1 years 6 8.2; 57 men and 86 women) were studied. APOE4 genetic status was associated with lower OEF (noncarriers, 41.1% 6 5.8; one E4 allele, 40.1% 6 4.9; two E4 alleles, 36.7% 6 4.5; P = .03). Furthermore, among APOE4 carriers, lower OEF correlated with lower executive function scores (b = 0.079 z score for each percent change in OEF; P = .03). Amyloid burden and OEF were independently associated with APOE4 but were not associated with one another, suggesting that the effect of APOE4 on OEF is not mediated by amyloid. Conclusion MRI-based brain oxygen extraction shows that cognitively healthy carriers of the apolipoprotein E4 gene manifest diminished brain oxygen extraction capacity independent of amyloid burden. ©RSNA, 2019

Indexed as

AgedAmyloid beta-PeptidesApolipoprotein E4BrainFemaleGenotypeGeriatric AssessmentHumansLongitudinal StudiesMagnetic Resonance ImagingMaleOxygenProspective StudiesRisk FactorsAmyloid beta-PeptidesApolipoprotein E4Oxygen

Identifiers

PMID31012816
PMCPMC6604795
OpenAlexW2941683247

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