ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019
Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Effects of Selenocysteine Substitution on the Cyclotide Kalata B2.Chembiochem : a European journal of chemical biology · 2026Article
- Damping amyloid-associated conformational fluctuations in a protein by an engineered diselenide bridge.Protein science : a publication of the Protein Society · 2026Article
- Replacing of Cysteine with Selenocysteine: Biochemical Considerations, Computational Modeling, and Protein Engineering Applications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Sulfur-Dependent Disulfide Bond Disruption in Insulin Resistance: A Hypothesis.Advanced pharmaceutical bulletin · 2025Article
- Directing the oxidative folding of disulfide-rich peptides for enhanced engineering and applications.Chemical science · 2025Review
- Oxidative Folding of a Two-Chain Protein Having Three Interchain Disulfide Bonds. Synthesis of Bromelain Inhibitor VI Through Native Chain Assembly.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Seleno-relaxin analogues: effect of internal and external diselenide bonds on the foldability and a fibrosis-related factor of endometriotic stromal cells.RSC chemical biology · 2024Article
- Organic solvent enhances oxidative folding of disulfide-rich proteins.Nature chemistry · 2024Article
- Photochemical Transformations of Peptides Containing theACS omega · 2024Article
- Selenium chemistry for spatio-selective peptide and protein functionalization.Nature reviews. Chemistry · 2024Review
- Semisynthesis of A6-A11 lactam insulin.Journal of peptide science : an official publication of the European Peptide Society · 2024Article
- Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity.Communications chemistry · 2023Article
- Selenium in Peptide Chemistry.Molecules (Basel, Switzerland) · 2023Review
- Vortex Fluidic Mediated Oxidative Sulfitolysis of Oxytocin.Molecules (Basel, Switzerland) · 2022Article
- Diselenide crosslinks for enhanced and simplified oxidative protein folding.Communications chemistry · 2021Article
- Flexible Folding: Disulfide-Containing Peptides and Proteins Choose the Pathway Depending on the Environments.Molecules (Basel, Switzerland) · 2021Review
- Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights the Distinction between External and Internal Diselenide Bridges.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Intein-mediated recombinant expression of monomeric B22Asp desB30 insulin.BMC biotechnology · 2020Article
- Article
- Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability.Journal of medicinal chemistry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Insulin analogues, mainstays in the modern treatment of diabetes mellitus, exemplify the utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the individual A and B chains were accomplished in the early 1960s, their combination to form native insulin remains inefficient because of competing disulfide pairing and aggregation. To overcome these limitations, we envisioned an alternative approach: pairwise substitution of cysteine residues with selenocysteine (Sec, U). To this end, Cys
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.