Evidence map›Paper›PMID 31012313›Full record

ArticleACS infectious diseases2019

Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities.

Xinxin Yang, Tianao Yuan, Rui Ma, Kieran I Chacko, Melissa Smith, Gintaras Deikus, Robert Sebra, Andrew Kasarskis, Harm van Bakel, Scott G Franzblau and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Mce transport systems inJournal of bacteriology · 2026
    Review
  2. Article
  3. ACS chemical biology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Reductive Power Generated byFrontiers in cellular and infection microbiology · 2021
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Xinxin YangDepartment of Chemistry , Stony Brook University , 100 John S. Toll Drive , Stony Brook , New York 11794-3400 , United States.
Tianao YuanDepartment of Chemistry , Stony Brook University , 100 John S. Toll Drive , Stony Brook , New York 11794-3400 , United States.ORCID 0000-0002-4700-8654
Rui MaInstitute for Tuberculosis Research , University of Illinois at Chicago , 833 South Wood Street, 425 PHARM , Chicago , Illinois 60612-7231 , United States.
Kieran I ChackoDepartment of Genetics and Genomic Sciences , Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , Box 1498, New York City , New York 10029 , United States.
Melissa SmithDepartment of Genetics and Genomic Sciences , Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , Box 1498, New York City , New York 10029 , United States.
Gintaras DeikusDepartment of Genetics and Genomic Sciences , Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , Box 1498, New York City , New York 10029 , United States.
Robert SebraDepartment of Genetics and Genomic Sciences , Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , Box 1498, New York City , New York 10029 , United States.
Andrew KasarskisDepartment of Genetics and Genomic Sciences , Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , Box 1498, New York City , New York 10029 , United States.
Harm van BakelDepartment of Genetics and Genomic Sciences , Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place , Box 1498, New York City , New York 10029 , United States.
Scott G FranzblauInstitute for Tuberculosis Research , University of Illinois at Chicago , 833 South Wood Street, 425 PHARM , Chicago , Illinois 60612-7231 , United States.ORCID 0000-0002-8698-0243
Nicole S SampsonDepartment of Chemistry , Stony Brook University , 100 John S. Toll Drive , Stony Brook , New York 11794-3400 , United States.ORCID 0000-0002-2835-7760
Icahn School of Medicine at Mount Sinai · USStony Brook University · USUniversity of Illinois Chicago · USStellenbosch University · ZA

Funding

Investigating genomic factors and microbiome features that impact CDI transmission and prognosisR01AI119145 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASHIR, ALI M, VAN BAKEL, HARM · 2015 to 2019
$4.2M
Establishing a Long Island Bioscience HubU01HL127522 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI RUBIN, CLINTON T · 2015 to 2017
$3.0M
Validating cholesterol-mediated Mycobacterium tuberculosis resistance to oxidative stress as a drug targetR01AI134054 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S · 2017 to 2021
$2.0M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
NHLBI NIH HHS U01 HL127522NIAID NIH HHS HHSN272201100009CNIAID NIH HHS HHSN272201100009INIAID NIH HHS R01 AI119145NIAID NIH HHS R01 AI134054NIH HHS S10 OD018522
6 · The paper itself

Abstract

One-third of the world's population carries

Indexed as

Antitubercular AgentsAzasteroidsBacterial ProteinsDiarylquinolinesDown-RegulationDrug Resistance, BacterialDrug SynergismGene Expression Regulation, BacterialIsoniazidMolecular StructureMycobacterium tuberculosisRegulonSmall Molecule LibrariesStructure-Activity RelationshipAntitubercular AgentsAzasteroidsBacterial ProteinsbedaquilineDiarylquinolinesIsoniazidSmall Molecule Librariescholesterolcodruglow oxygen

Identifiers

PMID31012313
PMCPMC6630528
OpenAlexW2941463367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.