Evidence map›Paper›PMID 31012282›Full record

Observational studyBrain and behavior2019

Matrix metalloproteinase-9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation.

Xingyang Yi, Qiang Zhou, Guo Sui, Daofeng Fan, Yongyin Zhang, Minjie Shao, Zhao Han, Hua Luo, Jing Lin, Ju Zhou

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Xingyang YiDepartment of Neurology, People's Hospital of Deyang City, Deyang, China.ORCID 0000-0002-1901-5486
Qiang ZhouDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Guo SuiNursing Department, The People's Hospital of Deyang City, Deyang, China.
Daofeng FanDepartment of Neurology, The Affiliated Longyan first Hospital of Fujian Medical University, Longyan, China.
Yongyin ZhangDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Minjie ShaoDepartment of Neurology, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, China.
Zhao HanDepartment of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Hua LuoDepartment of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jing LinDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ju ZhouDepartment of Neurology, People's Hospital of Deyang City, Deyang, China.
Wenzhou Medical University · CNDeyang Stomatological Hospital · CNAffiliated Hospital of Southwest Medical University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe mechanisms of ischemic stroke severity and early neurologic deterioration (END) are not fully understood. The aim of the present study was to investigate the association of six variants in MMP-9 gene with ischemic stroke severity and the risk for END in ischemic stroke (IS) patients with atrial fibrillation (AF).

methodsThis was a multi-center, prospective, observational study of 615 acute IS patients with AF admitted to six participating hospitals between June 2016 and October 2017. Ischemic stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) score on admission. END was defined as an increase of four or more points in NIHSS within 10 days of admission. Six variants of MMP-9 gene were examined using mass spectrometry.

resultsAmong the 615 enrolled patients, 112 (18.2%) patients presented with moderate or severe stroke (NIHSS score ≥16), and 108 (17.6%) patients suffered from END within 10 days of admission. Multiple logistic analysis showed that prestroke antiplatelet therapy, prestroke anticoagulant therapy, rs3918242 CT/TT, and rs3787268 AG/GG were independent predictors for stroke severity. Cox proportional hazard regression revealed that diabetes mellitus, prestroke antiplatelet therapy, prestroke anticoagulant therapy, rs1056628 AC/CC, and rs3918242 CT/TT were independently associated with the risk of END.

conclusionsThe incidence of moderate or severe stroke and END was very common in acute IS patients with AF. MMP-9 polymorphisms were independently associated with severe stroke and higher risk of END, and prestroke antithrombotic treatment was associated with less severe stroke and lower risk of END in patients with AF.

Indexed as

AgedAnticoagulantsAtrial FibrillationBrain IschemiaDisease ProgressionFemaleHumansIncidenceMaleMatrix Metalloproteinase 9Middle AgedNervous System DiseasesPolymorphism, GeneticProspective StudiesRisk FactorsStrokeAnticoagulantsMatrix Metalloproteinase 9MMP9 protein, humanatrial fibrillationearly neurological deteriorationischemic strokeMMP-9 variantsstroke severity

Identifiers

PMID31012282
PMCPMC6576155
OpenAlexW2941353000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.