ArticleMicrobial biotechnology2019
Functional assessment of hydrophilic domains of late embryogenesis abundant proteins from distant organisms.
Article in Microbial biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Deciphering the PgLEA2-50 interactome: implications for abiotic stress responses inPlant signaling & behavior · 2026Article
- Surviving desiccation: key factors underlying tolerance in prokaryotes and eukaryotes.Protoplasma · 2025Review
- Protein Disorder in Plant Stress Adaptation: From Late Embryogenesis Abundant to Other Intrinsically Disordered Proteins.International journal of molecular sciences · 2024Review
- Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties.PNAS nexus · 2024Article
- Enzyme stabilization and thermotolerance function of the intrinsically disordered LEA2 proteins from date palm.Scientific reports · 2023Article
- Artificial Proteins Designed from G3LEA Contribute to Enhancement of Oxidation Tolerance inAntioxidants (Basel, Switzerland) · 2023Article
- Article
- LEA motifs promote desiccation tolerance in vivo.BMC biology · 2021Article
- Multi-locus genome-wide association mapping for spike-related traits in bread wheat (Triticum aestivum L.).BMC genomics · 2021Article
- Modular Assembly of Ordered Hydrophilic Proteins Improve Salinity Tolerance inInternational journal of molecular sciences · 2021Article
- Pleiotropic roles of late embryogenesis abundant proteins ofComputational and structural biotechnology journal · 2021Review
- Transcriptome Analysis Identified Coordinated Control of Key Pathways Regulating Cellular Physiology and Metabolism uponJournal of fungi (Basel, Switzerland) · 2020Article
- Protective Functions of Group 3 Late Embryogenesis Abundant (G3LEA) Proteins inIndian journal of microbiology · 2020Article
- Late Embryogenesis Abundant Protein-Client Protein Interactions.Plants (Basel, Switzerland) · 2020Review
- Mechanisms of Desiccation Tolerance: Themes and Variations in Brine Shrimp, Roundworms, and Tardigrades.Frontiers in physiology · 2020Review
- Functional assessment of hydrophilic domains of late embryogenesis abundant proteins from distant organisms.Microbial biotechnology · 2019Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late embryogenesis abundant (LEA) proteins play a protective role during desiccation and oxidation stresses. LEA3 proteins are a major group characterized by a hydrophilic domain (HD) with a highly conserved repeating 11-amino acid motif. We compared four different HD orthologs from distant organisms: (i) DrHD from the extremophilic bacterium Deinococcus radiodurans; (ii) CeHD from the nematode Caenorhabditis elegans; (iii) YlHD from the yeast Yarrowia lipolytica; and (iv) BnHD from the plant Brassica napus. Circular dichroism spectroscopy showed that all four HDs were intrinsically disordered in phosphate buffer and then folded into α-helical structures with the addition of glycerol or trifluoroethanol. Heterologous HD expression conferred enhanced desiccation and oxidation tolerance to Escherichia coli. These four HDs protected the enzymatic activities of lactate dehydrogenase (LDH) by preventing its aggregation under desiccation stress. The HDs also interacted with LDH, which was intensified by the addition of hydrogen peroxide (H
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