Evidence map›Paper›PMID 31012252›Full record

ReviewGenes, brain, and behavior2019

National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies.

Hannah M Cates, Chelsie E Benca-Bachman, Giordano de Guglielmo, Sarah A Schoenrock, Chang Shu, Marsida Kallupi

Open access · bronzeAbstract readReview
In one paragraph

Review in Genes, brain, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Hannah M CatesFriedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-9413-0847
Chelsie E Benca-BachmanDepartment of Psychology, Emory University, Atlanta, Georgia.
Giordano de GuglielmoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California.ORCID 0000-0002-4782-7430
Sarah A SchoenrockDepartment of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-7345-444X
Chang ShuDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Marsida KallupiDepartment of Neuroscience, The Scripps Research Institute, La Jolla, California.ORCID 0000-0002-8688-709X
Scripps Research Institute · USAllen Institute for Brain Science · USEmory University · USUniversity of North Carolina at Chapel Hill · USYale University · US

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3M
Project 5: Circadian RhythmsP50DA039841 · NIDA · JACKSON LABORATORY · PI LAURA G REINHOLDT · 2016 to 2026
$26.2M
Identification of Genetic Variants that Contribute to Compulsive Cocaine Intakein RatsU01DA043799 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Olivier George, Abraham A Palmer · 2017 to 2026
$7.9M
Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsiveOxycodone Intake in Outbred RatsU01DA044451 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Olivier George, Abraham A Palmer · 2018 to 2026
$7.3M
Alcohol Vapor Self-Administration in RatsR01AA022977 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Olivier George · 2014 to 2026
$5.1M
(Epi)genetic Risk Architectures in Opioid Dependent BrainR01DA043980 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI AKBARIAN, SCHAHRAM, JOHNSON, ERIC OTTO · 2017 to 2021
$4.9M
NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENTR01AA008459 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI GEORGE, OLIVIER · 1990 to 2013
$4.2M
The Kinship Risk Score: An Integrative Tool to Prioritize Alcohol and Drug-Addiction Related Genes for Enhanced Risk PredictionDP1DA042103 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2017 to 2021
$2.3M
Neuronal ensembles of compulsive alcohol drinkingR01AA026081 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GEORGE, OLIVIER · 2017 to 2021
$2.0M
Integrative Prioritization of Alcohol and Drug-Addiction Related Genetic LociR01DA042742 · NIDA · EMORY UNIVERSITY · PI PALMER, ROHAN HUGH CRAIG · 2018 to 2022
$1.7M
Methylome-wide and mQTL analysis of HIV progression in the context of cocaine useR01DA042691 · NIDA · YALE UNIVERSITY · PI XU, KE · 2016 to 2019
$1.6M
NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01AA006420NIAAA NIH HHS R01 AA008459NIAAA NIH HHS R01 AA022977NIAAA NIH HHS R01 AA026081NIAAA NIH HHS R01AA026081NIAAA NIH HHS R01AA042691NIDA NIH HHS DP1 DA042103NIDA NIH HHS DP1DA042103NIDA NIH HHS P50 DA039841NIDA NIH HHS P50DA039841NIDA NIH HHS R01 DA042691NIDA NIH HHS R01 DA042742NIDA NIH HHS R01DA042742NIDA NIH HHS R01 DA043980NIDA NIH HHS R01DA043980NIDA NIH HHS U01 DA043799NIDA NIH HHS U01DA043799NIDA NIH HHS U01 DA044451NIDA NIH HHS U01DA044451
6 · The paper itself

Abstract

The National Institute on Drug Abuse Genetics and Epigenetics Cross-Cutting Research Team convened a diverse group of researchers, clinicians, and healthcare providers on the campus of the University of California, San Diego, in June 2018. The goal was to develop strategies to integrate genetics and phenotypes across species to achieve a better understanding of substance use disorders through associations between genotypes and addictive behaviors. This conference (a) discussed progress in harmonizing large opioid genetics cohorts, (b) discussed phenotypes that are used for genetics studies in humans, (c) examined phenotypes that are used for genetics studies in animal models, (d) identified synergies and gaps in phenotypic analyses of human and animal models and (e) identified strategies to integrate genetics and genomics data with phenotypes across species. The meeting consisted of panels that focused on phenotype harmonization (Dr. Laura Bierut, Dr. Olivier George, Dr. Dan Larach and Dr. Sesh Mudumbai), translating genetic findings between species (Dr. Elissa Chesler, Dr. Gary Peltz and Dr. Abraham Palmer), interpreting and understanding allelic variations (Dr. Vanessa Troiani and Dr. Tamara Richards) and pathway conservation in animal models and human studies (Dr. Robert Hitzemann, Dr. Huda Akil and Dr. Laura Saba). There were also updates that were provided by large consortia (Dr. Susan Tapert, Dr. Danielle Dick, Dr. Howard Edenberg and Dr. Eric Johnson). Collectively, the conference was convened to discuss progress and changes in genome-wide association studies.

Indexed as

Consensus Statements as TopicDisease Models, AnimalNational Institute on Drug Abuse (U.S.)AnimalsGenomicsHumansPractice Guidelines as TopicSubstance-Related DisordersTranslational Research, BiomedicalUnited Statesaddiction modelsbig datadruggenetic variantsGWASopioidssubstance use disorders

Identifiers

PMID31012252
PMCPMC7891887
OpenAlexW2941822411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.