ArticleChembiochem : a European journal of chemical biology2019
Physicochemical Characterization of Polymer-Stabilized Coacervate Protocells.
Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Patchy Membrane-Directed Multiphase Complex Coacervation.Journal of the American Chemical Society · 2026Article
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Dynamic Covalent Boronate Chemistry forJournal of the American Chemical Society · 2026Article
- Complex Coacervate Emulsions as a Strategy to Stabilize Enzymes for Catalysis in Organic Solvents.ACS macro letters · 2026Article
- Engineering Motile Coacervate Droplets via Nanomotor Stabilization.Journal of the American Chemical Society · 2025Article
- Biomolecule-Based Coacervation: Mechanisms, Applications, and Future Perspectives in Biomedical and Biotechnological Fields.Biomolecules · 2025Review
- Universal membranization of synthetic coacervates and biomolecular condensates towards ultrastability and spontaneous emulsification.Nature chemistry · 2025Article
- Converging frontiers in biomolecular condensate and synthetic cell research.npj biomedical innovations · 2025Review
- Article
- Tuning of Cationic Polymer Functionality in Complex Coacervate Artificial Cells for Optimized Enzyme Activity.Biomacromolecules · 2024Article
- Membranized Coacervate Microdroplets: from Versatile Protocell Models to Cytomimetic Materials.Accounts of chemical research · 2023Review
- DNA-Mediated Protein Shuttling between Coacervate-Based Artificial Cells.Angewandte Chemie (International ed. in English) · 2022Article
- Engineering transient dynamics of artificial cells by stochastic distribution of enzymes.Nature communications · 2021Article
- Engineering of Biocompatible Coacervate-Based Synthetic Cells.ACS applied materials & interfaces · 2021Article
- Therapeutics-how to treat phase separation-associated diseases.Emerging topics in life sciences · 2020Review
- Programmed spatial organization of biomacromolecules into discrete, coacervate-based protocells.Nature communications · 2020Article
- Liquid-Liquid Phase Separation in Crowded Environments.International journal of molecular sciences · 2020Review
- Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs.Journal of the American Chemical Society · 2020Article
- Physicochemical Characterization of Polymer-Stabilized Coacervate Protocells.Chembiochem : a European journal of chemical biology · 2019Article
- Mimicking Cellular Compartmentalization in a Hierarchical Protocell through Spontaneous Spatial Organization.ACS central science · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The bottom-up construction of cell mimics has produced a range of membrane-bound protocells that have been endowed with functionality and biochemical processes reminiscent of living systems. The contents of these compartments, however, experience semidilute conditions, whereas macromolecules in the cytosol exist in protein-rich, crowded environments that affect their physicochemical properties, such as diffusion and catalytic activity. Recently, complex coacervates have emerged as attractive protocellular models because their condensed interiors would be expected to mimic this crowding better. Here we explore some relevant physicochemical properties of a recently developed polymer-stabilized coacervate system, such as the diffusion of macromolecules in the condensed coacervate phase, relative to in dilute solutions, the buffering capacity of the core, the molecular organization of the polymer membrane, the permeability characteristics of this membrane towards a wide range of compounds, and the behavior of a simple enzymatic reaction. In addition, either the coacervate charge or the cargo charge is engineered to allow the selective loading of protein cargo into the coacervate protocells. Our in-depth characterization has revealed that these polymer-stabilized coacervate protocells have many desirable properties, thus making them attractive candidates for the investigation of biochemical processes in stable, controlled, tunable, and increasingly cell-like environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.