ArticleDepression and anxiety2019
Autonomic responses to fear conditioning among women with PTSD and dissociation.
Article in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients.European journal of psychotraumatology · 2022Pooled it
- Autonomic dysfunction in posttraumatic stress disorder indexed by heart rate variability: a meta-analysis.Psychological medicine · 2020Pooled it
- The progesterone to estradiol ratio predicts fear extinction in mice and humans.Neurobiology of stress · 2026Article
- Post-traumatic stress disorder.Nature reviews. Disease primers · 2026Review
- Bayesian multilevel modeling of group and participant level effect sizes: Stronger inter-individual differences in pupil dilation compared to EEG alpha power during aversive conditioning.bioRxiv : the preprint server for biology · 2025Article
- Dissociative Symptoms and Interoceptive Integration.Current topics in behavioral neurosciences · 2025Review
- The Neurophysiology of Interoceptive Disruptions in Trauma-Exposed Populations.Current topics in behavioral neurosciences · 2025Review
- A Prefrontal→Periaqueductal Gray Pathway Differentially Engages Autonomic, Hormonal, and Behavioral Features of the Stress-Coping Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Probing the neurocardiac circuit in trauma and posttraumatic stress.Journal of psychiatric research · 2024Article
- Preclinical Models of Chronic Stress: Adaptation or Pathology?Biological psychiatry · 2023Review
- Predicting Fear Extinction in Posttraumatic Stress Disorder.Brain sciences · 2023Article
- Differing associations of depersonalization with physiological response during rest and breath-focused mindfulness in a trauma-exposed female population.Journal of psychiatric research · 2023Article
- Sex-dependent risk factors for PTSD: a prospective structural MRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli.Neurobiology of stress · 2022Article
- Contrasting Associations Between Heart Rate Variability and Brainstem-Limbic Connectivity in Posttraumatic Stress Disorder and Its Dissociative Subtype: A Pilot Study.Frontiers in behavioral neuroscience · 2022Article
- Relevance of Objective Measures in Psychiatric Disorders-Rest-Activity Rhythm and Psychophysiological Measures.Current psychiatry reports · 2021Review
- Emotion dysregulation and dissociation contribute to decreased heart rate variability to an acute psychosocial stressor in trauma-exposed Black women.Journal of psychiatric research · 2021Article
- Thalamic volume and fear extinction interact to predict acute posttraumatic stress severity.Journal of psychiatric research · 2021Observational
- Dissociation in Borderline Personality Disorder: Recent Experimental, Neurobiological Studies, and Implications for Future Research and Treatment.Current psychiatry reports · 2021Review
- Disparities in women's health and clinical considerations from a translational science perspective: A narrative review and framework for future directions.Women's health (London, England)Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIndividuals with posttraumatic stress disorder (PTSD) demonstrate alterations in autonomic responses to fear conditioning, such as exaggerated startle and poor fear inhibition. However, there is a paucity of research on fear conditioning among individuals with PTSD and dissociative symptoms, which represents 10-30% of those with PTSD. The current study used a fear-potentiated startle (FPS) conditioning paradigm to examine autonomic responses among women with PTSD and a range of dissociative symptoms.
methodsParticipants included 39 women with PTSD and dissociation, and 53 women with PTSD with unknown levels of dissociation. The FPS paradigm consisted of conditioned stimuli associated and not associated with an aversive unconditioned stimulus. FPS response (eyeblink startle), electrocardiogram (ECG), and skin conductance response (SCR) were collected during the FPS paradigm.
resultsCompared to the PTSD-unknown dissociation sample, the PTSD-dissociation sample demonstrated significantly lower FPS during the last block of conditioning. Among the PTSD-dissociation sample, higher dissociation scores were associated with decreased FPS and SCR, and higher respiratory sinus arrhythmia (derived from ECG).
conclusionsResults suggest that autonomic responses to fear conditioning differ depending on the presence and severity of dissociative symptoms. Given that treatment response may differ depending on dissociative symptoms, it is important to understand the mechanisms that underlie different subtypes of PTSD and that may affect treatment response and outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.