ArticleJournal of magnetic resonance imaging : JMRI2019
Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Diffusion MRI reveals amyloid plaque-associated cellular signatures through spatial transcriptomic integration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- MicroRNA-200s attenuate demyelination caused by Angiostrongylus cantonensis in a mouse model by targeting phosphatase and tensin homolog.Neural regeneration research · 2026Article
- Detecting early brain susceptibility changes before demyelination in cuprizone mouse model using quantitative susceptibility mapping (QSM).NeuroImage · 2026Article
- Observations of anisotropic paramagnetic and diamagnetic susceptibility in the primate brain.bioRxiv : the preprint server for biology · 2025Article
- AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model.Journal of neuroinflammation · 2025Article
- Free Water-Corrected Fractional Anisotropy in Normal-Appearing White Matter as a Potential Neuroimaging Biomarker for Attention and Executive Function Impairment in Cerebral Small Vessel Disease.CNS neuroscience & therapeutics · 2025Article
- Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice.Frontiers in neuroanatomy · 2025Article
- Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation.Nature metabolism · 2024Article
- N-butyl-β-carboline-3-carboxylate (β-CCB) systemic administration promotes remyelination in the cuprizone demyelinating model in mice.Scientific reports · 2024Article
- Quantitative Analysis of Early White Matter Damage in Cuprizone Mouse Model of Demyelination Using 7.0 T MRI Multiparametric Approach.ASN neuro · 2024Article
- 3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice.Frontiers in neuroimaging · 2024Article
- Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis.Frontiers in molecular neuroscience · 2024Article
- Article
- Integrating multimodality magnetic resonance imaging to the Allen Mouse Brain Common Coordinate Framework.NMR in biomedicine · 2023Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- Characterization of white matter over 1-2 years in small vessel disease using MR-based quantitative susceptibility mapping and free-water mapping.Frontiers in aging neuroscience · 2022Article
- Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging.Frontiers in neuroscience · 2022Article
- Effects of Angular Resolution andCartilage · 2021Article
- Decompose quantitative susceptibility mapping (QSM) to sub-voxel diamagnetic and paramagnetic components based on gradient-echo MRI data.NeuroImage · 2021Article
- Demyelination and remyelination detected in an alternative cuprizone mouse model of multiple sclerosis with 7.0 T multiparameter magnetic resonance imaging.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundVarious studies by MRI exhibit that the corpus callosum (CC) is the most vulnerable to cuprizone administration, detecting the demyelination and remyelination process using different MRI parameters are, however, lacking. PURPOSE: To investigate the sensitivity of multiparametric MRI both in vivo and ex vivo for demyelination and remyelination. STUDY TYPE: Prospective. ANIMAL MODEL: A cuprizone mice model with an age-matched control group (n = 5), 4-week cuprizone exposure group followed by 9-week on a normal diet (n = 6), and a 13-week cuprizone exposure group (n = 6). FIELD STRENGTH/SEQUENCE: 3D gradient recalled echo, T ASSESSMENT: Quantification of DTI metrics, quantitative susceptibility mapping (QSM), and T STATISTICAL TESTS: Nonparametric permutation tests were used with a cluster-forming threshold as 3.09 (equivalent to P = 0.001), and the significant level as P = 0.05 with family-wise correction.
resultsIn vivo susceptibility values increased from -11.7 to -0.7 ppb (P < 0.001) in CC and from -13.7 to -5.1 ppb (P < 0.001) in the anterior commissure (AC) after the 13-week cuprizone exposure. Ex vivo susceptibility values increased from -25.4 to 7.4 ppb (P < 0.001) in CC and from -41.6 to -15.8 ppb (P < 0.001) in AC. Susceptibility values showed high variations to demyelination for in vivo studies (94.0% in CC, 62.8% in AC). Susceptibility values exhibited higher variations than radial diffusivity for ex vivo studies (129.1% vs. 28.3% in CC, 62.0% vs. 25.0% in AC). In addition to the differential susceptibility variations in different white matter tracts, intraregional demyelination variation was also present not only in CC but also in the AC area by voxel-based analysis. DATA
conclusionQSM is sensitive to the demyelination process of cuprizone exposure, which can be a complementary technique to conventional T LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:1852-1865.
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