ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2019
Clinicopathological Features and Prognosis of Small Gastric Gastrointestinal Stromal Tumors (GISTs).
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gastrointestinal Stromal Tumours (GIST): A Review of Cases from Nigeria.Journal of gastrointestinal cancer · 2020Pooled it
- Comparison of Endoscopic Cap External Snare Resection (ECESR) and Endoscopic Muscularis Dissection (EMD) for Small Gastric Submucosal Tumors (≤ 12 mm) Emerging from the Muscularis propria.Digestive diseases and sciences · 2026Article
- Patterns of Care and Outcomes of Patients with Small Gastrointestinal Stromal Tumors at a High-Volume Sarcoma Center.Annals of surgical oncology · 2024Article
- Development and validation of a preoperative risk nomogram prediction model for gastric gastrointestinal stromal tumors.Surgical endoscopy · 2024Article
- Endoscopic resection for the treatment of gastric gastrointestinal stromal tumors: a retrospective study from a large tertiary hospital in China.Surgical endoscopy · 2024Article
- Incidence Trends and Main Features of Gastro-Intestinal Stromal Tumours in a Mediterranean Region: A Population-Based Study.Cancers · 2023Article
- Small Gastric Stromal Tumors: An Underestimated Risk.Cancers · 2022Article
- Efficacy of endoscopic ultrasound in the evaluation of small gastrointestinal stromal tumors.World journal of gastroenterology · 2022Article
- Advances in endoscopic resection techniques of small gastric tumors originating from the muscularis propria.Frontiers in oncology · 2022Article
- Which size is the best cutoff for primary small gastric gastrointestinal stromal tumor?Journal of gastrointestinal oncology · 2020Article
- Controversies in EUS: Do we need miniprobes?Endoscopic ultrasoundArticle
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Abstract
backgroundThe aim of the present study was to evaluate the safety of endoscopic surgery, the clinicopathological features, and prognoses of small gastric gastrointestinal stromal tumors (GISTs).
methodsSmall gastric GIST patients (diameter: 0.10-2.00 cm) resected endoscopically in Zhongshan Hospital were retrospectively identified and clinicopathological features and outcomes were collected. The relationship between clinicopathological characteristics and tumor recurrence was analyzed. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal tumor diameter for predicting malignant potential.
resultsAll lesions were completely removed by endoscopy and En bloc resection was 98.5%. The most frequent location was the gastric fundus (60.3%) and the average diameter of all lesions was 1.20 cm (range: 0.10-2.00 cm). Mitoses were calculated as more than 5/50 HPF in 44 (6.8%) patients and nuclear atypia was moderate in 243 (37.5%) patients, severe in 1 (0.2%). Necrosis, mucosal infiltration, and vascular infiltration were detected in 8 (1.2%), 5 (0.7%), and 3 (0.5%) patients, respectively. Tumor size was positively correlated with mitotic index (P < 0.001) and nuclear atypia (P < 0.001). After a median follow-up of 54 months, four patients were confirmed local recurrence. ROC curve analysis identified 1.45 cm as the best cut-off value to predict malignant potential (95% CI: 0·694-0·774). Survival analysis showed that patients with tumor diameters larger than 1.45 cm were associated with more local recurrences after resection (P = 0.011).
conclusionsEndoscopic surgery is feasible and safe for small gastric GISTs, especially those in favorable locations. Small gastric GISTs bear a good prognosis as a whole but those with diameters larger than 1.45 cm should receive more intensive surveillance or undergo endoscopic surgery.
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