Evidence map›Paper›PMID 31012015›Full record

ArticleDoklady. Biochemistry and biophysics2019

Personalized Approach to Assessing mRNA Expression of Histidine-Rich Glycoprotein and Immunohistochemical Markers in Diseases of the Breast.

A I Autenshlyus, A V Golovanova, A A Studenikina, I I Brusentsov, A V Proskura, I P Zhurakovskiy, S A Arkhipov, S V Sidorov, V A Vavilin, V V Lyakhovich

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

A I AutenshlyusNovosibirsk State Medical University, Ministry of Health of the Russian Federation, 630091, Novosibirsk, Russia. lpciip@211.ru.
A V GolovanovaNovosibirsk State Medical University, Ministry of Health of the Russian Federation, 630091, Novosibirsk, Russia.
A A StudenikinaNovosibirsk State Medical University, Ministry of Health of the Russian Federation, 630091, Novosibirsk, Russia.
I I BrusentsovInstitute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia.
A V ProskuraResearch Institute of Molecular Biology and Biophysics, 630117, Novosibirsk, Russia.
I P ZhurakovskiyNovosibirsk State Medical University, Ministry of Health of the Russian Federation, 630091, Novosibirsk, Russia.
S A ArkhipovNovosibirsk State Medical University, Ministry of Health of the Russian Federation, 630091, Novosibirsk, Russia.
S V SidorovNational Research Novosibirsk State University, 630090, Novosibirsk, Russia.
V A VavilinResearch Institute of Molecular Biology and Biophysics, 630117, Novosibirsk, Russia.
V V LyakhovichResearch Institute of Molecular Biology and Biophysics, 630117, Novosibirsk, Russia.
Institute of Molecular Biology and Biophysics · RUMinistry of Health of the Russian Federation · RUNovosibirsk State Medical University · RUInstitute of Cytology and Genetics · RUNovosibirsk State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biopsy material of patients with malignant and benign breast diseases was examined. HRG mRNA expression was detected in 70% of cases in biopsy material obtained from patients with nonspecific invasive carcinoma and in 66.7% of cases in biopsy material of patients with benign breast diseases. Immunohistochemical analysis revealed expression of collagen II, the beta-1 integrin, and E-cadherin-markers of epithelial-mesenchymal transition. The use of RT-qPCR combined with immunohistochemical study made it possible to identify atypical cells, which can be regarded as precancerous changes, in individual patients.

Indexed as

Epithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticAdolescentAdultAgedAntigens, CDBiomarkers, TumorBreast NeoplasmsCadherinsFemaleHistidine-Rich GlycoproteinHumansMiddle AgedNeoplasm ProteinsProteinsAntigens, CDBiomarkers, TumorCadherinsCDH1 protein, humanHistidine-Rich GlycoproteinNeoplasm ProteinsProteins

Identifiers

PMID31012015
OpenAlexW2940558167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.