Evidence map›Paper›PMID 31012006›Full record

ArticleDoklady. Biochemistry and biophysics2019

Dynamics of in Vivo Metabolites Concentrations in Posttraumatic Period of Human Brain.

N A Semenova, P E Menshchikov, A V Manzhurtsev, M V Ublinskiy, T A Akhadov, S D Varfolomeev

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

N A SemenovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.
P E MenshchikovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.
A V ManzhurtsevEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia. Andrey.man.93@gmail.com.
M V UblinskiyEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.
T A AkhadovClinical and Research Institute of Emergency Pediatric Surgery and Traumatology, 127412, Moscow, Russia.
S D VarfolomeevEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the first time the intracellular concentrations of N-acetylaspartate (NAA), aspartate (Asp), and glutamate (Glu) were measured in human brain in vivo, and the effect of severe traumatic brain injury on NAA synthesis in acute and remote posttraumatic phases was revealed. In non-damaged (MRI-negative) lobes the next day after injury, Asp and Glu decreased by 45% and 35%, respectively, while NAA decreased only by 16%. A negative correlation between NAA and Asp/Glu ratio was found. The Glu level returned to the norm long after injury, Asp remained below the norm by 60%, NAA decreased by 65% relative to the norm, and Asp/Glu decreased significantly. The results obtained educe the leading role of neuronal aspartate-malate shuttle in NAA synthesis alterations.

Indexed as

BrainBrain Injuries, TraumaticMagnetic Resonance ImagingAdolescentAspartic AcidFemaleGlutamic AcidHumansMaleTime FactorsAspartic AcidGlutamic AcidN-acetylaspartate

Identifiers

PMID31012006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.