ReviewPituitary2019
Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management.
Review in Pituitary, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Safety and efficacy of endoscopic vs. microscopic approaches in pituitary adenoma surgery: A systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- The role of optical coherence tomography in the evaluation of para-chiasmal lesions: a systematic review and meta-analysis.Frontiers in ophthalmology · 2025Pooled it
- Postsurgical outcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis.Pituitary · 2023Pooled it
- "Tamoxifen for residual NF-PitNETs: A Proof-of-Concept study integrating receptor profiling, pilot trial, and target pathway analysis".Endocrine · 2025Trial
- Proteomic profile of bone in patients with acromegaly: new insights from a pilot exploratory study.Journal of endocrinological investigation · 2026Article
- The role of neuro-ophthalmology in post-operative follow-up after resection of non-functioning pituitary macroadenomas in the UK: a clinician practice survey.Eye (London, England) · 2026Article
- Exploring epigenome-proteome interactions underlying post-surgical progression of non-functioning pituitary adenomas using hypernetwork modelling.Journal of translational medicine · 2026Article
- Endoscopic endonasal resection of ectopic suprasellar pituitary neuroendocrine tumors: comparison of intra-stalk and extra-stalk tumors. Illustrative cases.Journal of neurosurgery. Case lessons · 2026Article
- The Limited Role of Hypocortisolism in the Development of Delayed Postoperative Hyponatremia After Pituitary Surgery.Pituitary · 2026Article
- [Visual field index and pituitary tumors resected by microsurgical transsphenoidal approach].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Endoscopic Versus Microscopic Transsphenoidal Surgery in the Treatment of Pituitary Adenoma: A Systematic Review.Cureus · 2026Review
- Proteomic insights into the invasiveness and tumor progression of non-functioning pituitary adenomas: A scoping review.Journal of neuroendocrinology · 2026Article
- Radiotherapy regimens and concurrent Cabergoline use for non-functioning pituitary neuroendocrine tumors: a large, single-center cohort.Endocrine · 2026Article
- Comprehensive evaluation and analysis of pituitary hormones in male patients with non-functional pituitary adenoma during the perioperative period.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Clinically informed preoperative risk stratification for MRI-defined non gross-total resection in nonfunctioning pituitary neuroendocrine tumors: a single-center internal validation study.Frontiers in physiology · 2026Article
- The utilization of preoperative DWI for pituitary macroadenoma surgical planning: Implications for neuroendoscopic surgery.Endocrine · 2025Article
- Risk factors and prognosis of visual and cranial nerve deficits in patients operated for pituitary tumor - with a focus on intrasellar pressure.Acta neurochirurgica · 2025Article
- Pituitary and Optic Tract Lesions Masquerading As Glaucoma: Highlighting Diagnostic Challenges.Cureus · 2025Article
- Article
- Evaluating pituitary tumor management: aligning with pituitary tumor centers of excellence criteria.Pituitary · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNon-functioning pituitary adenomas (NFPAs) are associated with impaired well-being, increased comorbidities, and reduced long-term survival. Data on optimal management of NFPAs around surgical treatment are scarce, and postoperative treatment and follow-up strategies have not been evaluated in prospective trials. Here, we review the preoperative, perioperative, and early postoperative management of patients with NFPAs.
methodsWe searched Medline and the Cochrane Library for articles published in English with the following items "Pituitary neoplasms AND Surgery" and "Surgery AND Hypopituitarism". Studies containing detailed analyses of the management of NFPAs in adult patients, including pituitary surgery, endocrine care, imaging, ophthalmologic assessment and long-term outcome were reviewed.
resultsTreatment options for NFPAs include active surveillance, surgical resection, and radiotherapy. Pituitary surgery is currently recommended as first-line treatment in patients with visual impairment due to adenomas compressing the optic nerves or chiasma. Radiotherapy is reserved for large tumor remnants or tumor recurrence following one or more surgical attempts. There is no consensus of optimal pre-, peri-, and postoperative management such as timing, frequency, and duration of endocrine, radiologic, and ophthalmologic assessments as well as management of smaller tumor remnants or tumor recurrence.
conclusionsIn clinical practice, there is a great variation in the treatment and follow-up of patients with NFPAs. We have, based on available data, suggested an optimal management strategy for patients with NFPAs in relation to pituitary surgery. Prospective trials oriented at drawing up strategies for the management of NFPAs are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.