SynthesisBrain imaging and behavior2020
Differential insular cortex sub-regional atrophy in neurodegenerative diseases: a systematic review and meta-analysis.
Synthesis in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Systematic Review of Different Neuroimaging Correlates in Mild Cognitive Impairment and Alzheimer's Disease.Clinical neuroradiology · 2021Pooled it
- Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds.npj aging · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Exploring the relationship between interoception and mental body representation in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Real-world walking patterns are associated with regional brain atrophy and white matter lesions in middle-aged and older people: a Watch Walk-UK Biobank study.GeroScience · 2026Article
- Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Subjective time perception in dementia: a behavioural and neuroanatomical analysis.Brain communications · 2026Article
- Characterizing Gray matter atrophy patterns associated with accelerometer-measured sedentary behavior: a population-based study.Brain imaging and behavior · 2025Article
- Acute hemichorea-hemiballism as the initial sign of cortical cerebral infarction: A case report.Neuroprotection (Chichester, England) · 2025Article
- Computed tomography-based nnU-Net for region-specific brain structural changes across the alzheimer's continuum and frontotemporal dementia subtypes.Scientific reports · 2025Article
- Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025Review
- Evaluation of registration-based vs. manual segmentation of rhesus macaque brain MRIs.Brain structure & function · 2024Article
- Comparison of Neurogenesis Promotion Effects between Cinnamoylquinic Acids in Neural Stem Cells from Adult Mice Brains.ACS chemical neuroscience · 2024Article
- Development of a prediction model for cognitive impairment of sarcopenia using multimodal neuroimaging in non-demented older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Lower in vivo locus coeruleus integrity is associated with lower cortical thickness in older individuals with elevated Alzheimer's pathology: a cohort study.Alzheimer's research & therapy · 2024Article
- Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?Journal of clinical medicine · 2024Review
- Neuroanatomical and neurocognitive correlates of delusion in Alzheimer's disease and mild cognitive impairment.BMC neurology · 2024Article
- Differential diagnosis of frontotemporal dementia subtypes with explainable deep learning on structural MRI.Frontiers in neuroscience · 2024Article
- Intrinsic functional and structural network organization in the macaque insula.Imaging neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insular cortex is proposed to function as a central brain hub characterized by wide-spread connections and diverse functional roles. As a result, its centrality in the brain confers high metabolic demands predisposing it to dysfunction in disease. However, the functional profile and vulnerability to degeneration varies across the insular sub-regions. The aim of this systematic review and meta-analysis is to summarize and quantitatively analyze the relationship between insular cortex sub-regional atrophy, studied by voxel based morphometry, with cognitive and neuropsychiatric deficits in frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). We systematically searched through Pubmed and Embase and identified 519 studies that fit our criteria. A total of 41 studies (n = 2261 subjects) fulfilled the inclusion criteria for the meta-analysis. The peak insular coordinates were pooled and analyzed using Anatomic Likelihood Estimation. Our results showed greater left anterior insular cortex atrophy in FTD whereas the right anterior dorsal insular cortex showed larger clusters of atrophy in AD and PD/DLB. Yet contrast analyses did not reveal significant differences between disease groups. Functional analysis showed that left anterior insular cortex atrophy is associated with speech, emotion, and affective-cognitive deficits, and right dorsal atrophy with perception and cognitive deficits. In conclusion, insular sub-regional atrophy, particularly the anterior dorsal region, may contribute to cognitive and neuropsychiatric deficits in neurodegeneration. Our results support anterior insular cortex vulnerability and convey the differential involvement of the insular sub-regions in functional deficits in neurodegenerative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.