ArticleBrain imaging and behavior2019
Imaging the effects of age on proactive control in healthy adults.
Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- A comprehensive study of cognitive control in healthy aging.Communications medicine · 2025Article
- Neuroanatomical Changes in the Stopping Network Across the Adult Lifespan Assessed With Quantitative and Diffusion MRI.Human brain mapping · 2025Article
- Age-Related Structural and Functional Changes of the Hippocampus and the Relationship with Inhibitory Control.Brain sciences · 2020Article
- The same, but different: Preserved distractor suppression in old age is implemented through an age-specific reactive ventral fronto-parietal network.Human brain mapping · 2020Article
- Threat bias and resting state functional connectivity of the amygdala and bed nucleus stria terminalis.Journal of psychiatric research · 2020Article
- Article
- Age-Related Changes in the Neural Processes of Reward-Directed Action and Inhibition of Action.Frontiers in psychology · 2020Article
- Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology.American journal of Alzheimer's disease and other dementiasReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previous research has reported reduced efficiency in reactive inhibition, along with reduced brain activations, in older adults. The current study investigated age-related behavioral and neural changes in proactive inhibition, and whether age may influence the relationship between proactive and reactive inhibition. One-hundred-and-forty-nine adults (18 to 72 years) underwent fMRI while performing a stop signal task (SST). Proactive inhibition was defined by the sequential effect, the correlation between the estimated probability of stop signal - p(Stop) - and go trial reaction time (goRT). P(Stop) was estimated trial by trial with a Bayesian belief model; reactive inhibition was defined by the stop signal reaction time (SSRT). Behaviorally the magnitude of sequential effect was not correlated with age, replicating earlier reports of spared proactive control in older adults. Age was associated with greater activations to p(Stop) in the lateral prefrontal cortex (PFC), paracentral lobule, superior parietal lobule, and cerebellum, and activations to goRT in the inferior occipital gyrus (IOG). Granger Causality analysis demonstrated that the PFC Granger caused IOG, with the PFC-IOG connectivity significantly correlated with p(Stop) in older but not younger adults. These findings suggest that the PFC and IOG activations and PFC-IOG connectivity may compensate for proactive control during aging. In contrast, while the activations of the ventromedial prefrontal cortex and caudate head to p(Stop) were negatively correlated with SSRT, relating proactive to reactive control, these activities did not vary with age. These findings highlighted distinct neural processes underlying proactive inhibition and limited neural plasticity to support cognitive control in the aging brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.