Evidence map›Paper›PMID 31011876›Full record

ArticleArchives of dermatological research2019

The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population.

Zita Szentkereszty-Kovács, Szilvia Fiatal, Andrea Szegedi, Dóra Kovács, Eszter Janka, Krisztina Herszényi, Péter Holló, Pernilla Nikamo, Mona Ståhle, Éva Remenyik and 1 more

Abstract read
In one paragraph

Article in Archives of dermatological research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Genetic Vulnerability to Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021
    Review
  5. Alcohol in Psoriasis-From Bench to Bedside.International journal of molecular sciences · 2021
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zita Szentkereszty-KovácsDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Szilvia FiatalDepartment of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
Andrea SzegediDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Dóra KovácsDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Eszter JankaDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Krisztina HerszényiDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
Péter HollóDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
Pernilla NikamoUnit of Dermatology and Venereology, Department of Medicine, Karolinska lnstitutet, Karolinska University Hospital, Stockholm, Sweden.
Mona StåhleUnit of Dermatology and Venereology, Department of Medicine, Karolinska lnstitutet, Karolinska University Hospital, Stockholm, Sweden.
Éva RemenyikDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Dániel TörőcsikDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. dtorocsik@gmail.com.ORCID http://orcid.org/0000-0002-6094-6266

Funding

GINOP-2.3.2 2016-00005H2020 Marie Skłodowska-Curie Actions () 627547 FP7-PEOPLE-2013-IEF
6 · The paper itself

Abstract

Alcohol intake affects in great the symptoms and life of  psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case-control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (OR

Indexed as

Alcohol DehydrogenaseAlcohol DrinkingAlcoholismGenetic Predisposition to DiseaseHumansHungaryMiddle AgedPolymorphism, Single NucleotidePsoriasisReceptors, Opioid, muRiskADH1B protein, humanAlcohol DehydrogenaseOPRM1 protein, humanReceptors, Opioid, muADH1B geneAlcohol consumptionOPRM1 genePopulation geneticsPsoriasis

Identifiers

PMID31011876
PMCPMC6594982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.