Evidence map›Paper›PMID 31011833›Full record

SynthesisClinical oral investigations2019

Treatment of actinic cheilitis: a systematic review.

Arthur Pias Salgueiro, Luciano Henrique de Jesus, Isadora Follak de Souza, Pantelis Varvaki Rados, Fernanda Visioli

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Arthur Pias SalgueiroOral Pathology Department, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2492, Room 503, Porto Alegre, RS, 90035-003, Brazil.
Luciano Henrique de JesusOral Pathology Department, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2492, Room 503, Porto Alegre, RS, 90035-003, Brazil.
Isadora Follak de SouzaOral Pathology Department, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2492, Room 503, Porto Alegre, RS, 90035-003, Brazil.
Pantelis Varvaki RadosOral Pathology Department, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2492, Room 503, Porto Alegre, RS, 90035-003, Brazil.
Fernanda VisioliOral Pathology Department, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2492, Room 503, Porto Alegre, RS, 90035-003, Brazil. fernanda.visioli@ufrgs.br.ORCID http://orcid.org/0000-0002-4033-8431
Universidade Federal do Rio Grande do Sul · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior None
6 · The paper itself

Abstract

objectivesActinic cheilitis is a potentially malignant disorder caused by excessive sun exposure. It affects the lower lip of individuals, mostly those with light skin color. Different treatments have been proposed for AC; however, no consensus has been reached on the best option available. MATERIALS AND

methodsThe present study describes the results of a computer-based systematic search conducted on electronic databases to identify the best therapies.

resultsA total of 29 journal articles were selected, and the results were divided according to the type of treatment employed: laser therapy, chemotherapy agents, surgical treatment, and application of anti-inflammatory agents. Clinically, photodynamic therapy showed positive results, with improvement in up to 100% of the patients; however, histopathological improvement varied greatly, from 16 to 100%. Among the chemotherapeutic agents assessed, imiquimod showed the best results: clinical improvement in 80 to 100% of the patients, and histopathological improvement in 73 to 100%. Regarding studies describing surgical approaches, the main focus was the search for the best technique, rather than the cure of AC. Finally, studies employing anti-inflammatory agents are sparse and have small samples, thus providing limited results.

conclusionThe scientific evidence available on the treatment of AC is scarce and heterogeneous, photodynamic therapy, and imiquimod application are promising. CLINICAL RELEVANCE: The study of the treatments for AC in the form of a systematic review allows us to evaluate the results against the different treatments. Being a potentially malignant lesion, it is important to seek evidence about the best results found.

Indexed as

Laser TherapyPhotochemotherapyCheilitisHumansLipActinic cheilitisImiquimodLaserSystematic reviewVermilionectomy

Identifiers

PMID31011833
OpenAlexW2942313555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.