Evidence map›Paper›PMID 31011786›Full record

ArticleAnalytical and bioanalytical chemistry2019

Combined hydrophilic interaction liquid chromatography-scanning field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry for untargeted metabolomics.

Katarzyna M Szykuła, Joris Meurs, Matthew A Turner, Colin S Creaser, James C Reynolds

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katarzyna M SzykułaCentre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK.
Joris MeursAdvanced Materials and Healthcare Technology Division, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Matthew A TurnerCentre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK.
Colin S CreaserCentre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK.
James C ReynoldsCentre for Analytical Science, Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK. j.c.reynolds@lboro.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Untargeted metabolite profiling of biological samples is a challenge for analytical science due to the high degree of complexity of biofluids. Isobaric species may also not be resolved using mass spectrometry alone. As a result of these factors, many potential biomarkers may not be detected or are masked by co-eluting interferences in conventional LC-MS metabolomic analyses. In this study, a comprehensive liquid chromatography-mass spectrometry workflow incorporating a fast-scanning miniaturised high-field asymmetric waveform ion mobility spectrometry separation (LC-FAIMS-MS) is applied to the untargeted metabolomic analysis of human urine. The time-of-flight mass spectrometer used in the study was scanned at a rate of 20 scans s

Indexed as

MetabolomicsBiomarkersChromatography, LiquidFemaleHumansIon Mobility SpectrometryMaleMass SpectrometryReproducibility of ResultsBiomarkersBioanalytical methodsDifferential mobilityIon mobilityMass spectrometryMetabolomicsSeparations

Identifiers

PMID31011786
PMCPMC6718375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.