ArticleAdvances in radiation oncology
Quantitative temporal diffusion spectroscopy as an early imaging biomarker of radiation therapeutic response in gliomas: A preclinical proof of concept.
Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- MATI: A GPU-accelerated toolbox for microstructural diffusion MRI simulation and data fitting with a graphical user interface.Magnetic resonance imaging · 2025Article
- Engineering clinical translation of OGSE diffusion MRI.Magnetic resonance in medicine · 2025Review
- Imaging Microstructural Parameters of Breast Tumor in Patient Using Time-Dependent Diffusion: A Feasibility Study.Diagnostics (Basel, Switzerland) · 2025Article
- Assessing tumor microstructure with time-dependent diffusion imaging: Considerations and feasibility on clinical MRI and MRI-Linac.Medical physics · 2025Article
- Diffusion time dependency of extracellular diffusion.Magnetic resonance in medicine · 2023Article
- Towards differentiation of brain tumor from radiation necrosis using multi-parametric MRI: Preliminary results at 4.7 T using rodent models.Magnetic resonance imaging · 2022Article
- MR cell size imaging with temporal diffusion spectroscopy.Magnetic resonance imaging · 2021Review
- Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans.Journal of neuroscience methods · 2021Article
- MRI-cytometry: Mapping nonparametric cell size distributions using diffusion MRI.Magnetic resonance in medicine · 2021Article
- Mapping hepatocyte size in vivo using temporal diffusion spectroscopy MRI.Magnetic resonance in medicine · 2020Article
- Diffusion model comparison identifies distinct tumor sub-regions and tracks treatment response.Magnetic resonance in medicine · 2020Article
- MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy.Journal for immunotherapy of cancer · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis study aims to test the ability of quantitative temporal diffusion spectroscopy (qTDS) to assess cellular changes associated with radiation-induced cell death in a rat glioma model. METHODS AND MATERIALS: Tumor response to a single fraction of 20 Gy of x-ray radiation was investigated in a rat glioma (9L) model. Tumor response was monitored longitudinally at postinoculation days 21, 23, and 25, using a specific implementation of qTDS with acronym IMPULSED (Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion), as well as conventional diffusion and high-resolution anatomic imaging. IMPULSED method combines diffusion-weighted signals acquired over a range of diffusion times that are then analyzed and interpreted using a theoretical model of water diffusion in tissues, which generates parametric maps depicting cellular and subcellular structural information on a voxel-wise basis. Results from different metrics were compared statistically.
resultsA single dose of 20 Gy x-ray radiation significantly prolonged survival of 9L-bearing rats. The mean cell sizes of irradiated tumors decreased (
conclusionsThis proof-of-concept study demonstrates the IMPULSED method to be a new method for deriving quantitative microstructural parameters in a preclinical tumor model. The method provides unique information based on the diffusion time dependency of diffusion magnetic resonance imaging, which cannot be obtained by conventional diffusion weighted imaging methods, and the results have a close correlation with primary biologic markers of treatment efficacy, such as cell death and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.