ArticleHeliyon2019
Polyethylene glycol (PEG) decorated graphene oxide nanosheets for controlled release curcumin delivery.
Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Nano-Enabled Potentiation of a Lead Mono-Carbonyl Curcumin Analogue via PEGylated Graphene Oxide for Enhanced Glycemic Control.Pharmaceutics · 2026Article
- Article
- Recent Advances in the Design and Structural/Functional Regulations of Biomolecule-Reinforced Graphene Materials for Bone Tissue Engineering Applications.Small science · 2025Review
- Graphene-Based Nanomaterials in Photodynamic Therapy: Synthesis Strategies, Functional Roles, and Clinical Translation for Tumor Treatment.International journal of nanomedicine · 2025Review
- Stimuli-responsive Graphene-polysaccharide Nanocomposites for Drug Delivery and Tissue Engineering.Current organic synthesis · 2025Review
- Comparative performance analysis of mussel-inspired polydopamine, polynorepinephrine, and poly-α-methyl norepinephrine in electrochemical biosensors.Mikrochimica acta · 2024Article
- Article
- Multifaceted Characterization for the Hepatic Clearance of Graphene Oxide and Size-Related Hepatic Toxicity.Molecules (Basel, Switzerland) · 2024Article
- Preparation and characterization of a curcumin nanoemulsion gel for the effective treatment of mycoses.Scientific reports · 2023Article
- Poly(ethylene glycol)-Engrafted Graphene Oxide for Gene Delivery and Nucleic Acid Amplification.Materials (Basel, Switzerland) · 2023Review
- Neutralizing tumor-related inflammation and reprogramming of cancer-associated fibroblasts by Curcumin in breast cancer therapy.Scientific reports · 2023Article
- Relationship between the Polymer Blend Using Chitosan, Polyethylene Glycol, Polyvinyl Alcohol, Polyvinylpyrrolidone, and Antimicrobial Activities againstPharmaceutics · 2023Article
- Graphene Oxide Nanostructures as Nanoplatforms for Delivering Natural Therapeutic Agents: Applications in Cancer Treatment, Bacterial Infections, and Bone Regeneration Medicine.Nanomaterials (Basel, Switzerland) · 2023Review
- Article
- Article
- Photo-Antibacterial Activity of Two-Dimensional (2D)-Based Hybrid Materials: Effective Treatment Strategy for Controlling Bacterial Infection.Antibiotics (Basel, Switzerland) · 2023Review
- Graphene-based nanomaterials for stimuli-sensitive controlled delivery of therapeutic molecules.Frontiers in bioengineering and biotechnology · 2023Review
- Physicochemical, Structural, and In Vitro Gastrointestinal Tract Release Properties of Sodium Alginate-Based Cryogel Beads Filled with Hydroxypropyl Distarch Phosphate as a Curcumin Delivery System.Molecules (Basel, Switzerland) · 2022Article
- Graphene Oxide Nanoplatforms to Enhance Cisplatin-Based Drug Delivery in Anticancer Therapy.Nanomaterials (Basel, Switzerland) · 2022Article
- Effect of Fabrication Method on the Thermo Mechanical and Electrical Properties of Graphene Doped PVDF Nanocomposites.Nanomaterials (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, the use of nanostructures in various medical and biological fields such as drug delivery in cancer treatment is increasing. Among the nanostructures, graphene oxide (GO) is an excellent candidate for drug delivery application because of its unique properties. For more stability, GO can bind with various polymers by its carboxyl, hydroxyl and epoxy functional groups. In this study, firstly GO synthesized by the improved Hummers chemical method and then polyethylene glycol polymer was conjugated to it by using EDC/NHS catalyst. Finally, curcumin (Cur) as anti-cancer drug has been loaded onto the PEGylated graphene oxide (GO-PEG). Next, curcumin loaded onto PEGylated graphene oxide (GO-PEG-Cur) were evaluated by using ultraviolet, Fourier transform infrared spectroscopy, differential scanning calorimeter, atomic microscopic force and dynamic light scattering. The amount of loaded drug was calculated about 4.5% with the help of the standard curcumin curve and UV/Vis spectrometer. Also, the result of release shows that maximum drug release rate for this nanocarrier in pH 5.5 and 7.4 was measured 50% and 60%, respectively, after 96 hours. The results showed that the zeta-potential analysis of GO-PEG-Cur was about -13.9 mV that expresses a negative surface charge for produced nanocarrier.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.