ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Functional Connectome Predicts Cognition and Links White Matter Hyperintensity Burden to Cognitive Impairment Across the Vascular Cognitive Impairment Continuum.Brain sciences · 2026Article
- Interactive effect of retinal microvascular impairment and larger lesion diameter on cognitive impairment in lacunar infarction.Alzheimer's research & therapy · 2026Article
- Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals.Neurobiology of aging · 2025Article
- Reshaped functional connectivity gradients in acute ischemic stroke.NeuroImage. Clinical · 2025Article
- Infarct volume as a predictor and therapeutic target in post-stroke cognitive impairment.Frontiers in medicine · 2025Review
- Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.Brain : a journal of neurology · 2024Article
- Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Strategic white matter hyperintensity locations associated with post-stroke cognitive impairment: A multicenter study in 1568 stroke patients.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients.medRxiv : the preprint server for health sciences · 2024Article
- Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- National and international collaborations to advance research into vascular contributions to cognitive decline.Cerebral circulation - cognition and behavior · 2024Article
- Disentangling poststroke cognitive deficits and their neuroanatomical correlates through combined multivariable and multioutcome lesion-symptom mapping.Human brain mapping · 2023Article
- Bayesian stroke modeling details sex biases in the white matter substrates of aphasia.Communications biology · 2023Article
- Spatial distributions of white matter hyperintensities on brain MRI: A pooled analysis of individual participant data from 11 memory clinic cohorts.NeuroImage. Clinical · 2023Article
- Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury.Brain structure & function · 2022Article
- Association of Lesion Location and Fatigue Symptoms After Ischemic Stroke: A VLSM Study.Frontiers in aging neuroscience · 2022Article
- Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke.NeuroImage. Clinical · 2022Article
- Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts.International journal of stroke : official journal of the International Stroke Society · 2021Article
- Post-Stroke Cognitive Impairment: Pathophysiological Insights into Brain Disconnectome from Advanced Neuroimaging Analysis Techniques.Journal of stroke · 2021Review
Corrections and comments
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Authors and funding
32 authors.
Funding
Abstract
introductionThe Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.
methodsCohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage.
resultsForty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. DISCUSSION: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
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