Evidence map›Paper›PMID 31011557›Full record

ReviewAdvanced pharmaceutical bulletin2019

Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings.

Fereshteh Farajdokht, Mehdi Farhoudi, Alireza Majdi, Masumeh Zamanlu, Saeed Sadigh-Eteghad, Shabnam Vahedi, Javad Mahmoudi

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced pharmaceutical bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fereshteh FarajdokhtNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0001-5349-6028
Mehdi FarhoudiNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-4972-9316
Alireza MajdiNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-2990-4762
Masumeh ZamanluNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-6326-8448
Saeed Sadigh-EteghadNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-2872-1072
Shabnam VahediNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-4087-9630
Javad MahmoudiNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-0589-9812
Tabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. Here we reviewed current understanding of testosterone (TES) neuroprotective activity against ischemic stroke and mechanisms underlying these effects in aging. TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death. Given this, a better understanding of the neuroprotective roles of TES may propose an effective therapeutic strategy to improve the quality of life and decrease androgen-related cerebrovascular problems in the aging men.

Indexed as

ApoptosisMale sexOxidative stressStrokeTestosterone

Identifiers

PMID31011557
PMCPMC6468219
OpenAlexW2917354369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.