ArticleCureus2019
Disparities in the Use of Single-fraction Stereotactic Radiosurgery for the Treatment of Brain Metastases From Non-small Cell Lung Cancer.
Article in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Geographic Trends and Disparities in Meningioma Mortality: A National Observational Study from 1999 to 2020 Utilizing the CDC Wonder Database.Journal of neurological surgery. Part B, Skull base · 2026Article
- Disparities in stereotactic radiosurgery receipt in patients with brain metastases from non-small cell lung cancer.Journal of neuro-oncology · 2026Article
- Evaluation of disparities in timely stereotactic radiosurgery for brain metastases in a safety net hospital system through a centralized workflow.Journal of neuro-oncology · 2026Article
- Dual optimization in single-isocenter radiosurgery for multiple brain metastases: a dosimetric planning study.Frontiers in oncology · 2026Article
- Stereotactic radiosurgery for brain metastases: evolving practice patterns from the national cancer database (2004-2020).Journal of neuro-oncology · 2025Article
- Article
- Disparities in Neuro-Oncology.Current neurology and neuroscience reports · 2023Review
- Stereotactic Body Radiation Therapy for Spine Metastases-Findings from an Australian Population-Based Study.Current oncology (Toronto, Ont.) · 2023Article
- Variations in whole brain radiation therapy fractionation for brain metastases in Victoria.Journal of medical imaging and radiation oncology · 2022Article
- Impact of socio-economic factors on radiation treatment after resection of metastatic brain tumors: trends from a private insurance database.Journal of neuro-oncology · 2022Article
- Socioeconomic Disparities in Brain Metastasis Survival and Treatment: A Population-Based Study.World neurosurgery · 2022Article
- Factors associated with the use of salvage whole brain radiation therapy versus salvage stereotactic radiosurgery after initial stereotactic radiosurgery for brain metastases.Journal of radiosurgery and SBRT · 2022Article
- The association of health insurance with the survival of cancer patients with brain metastases at diagnosis.Technical innovations & patient support in radiation oncology · 2021Article
- Sociodemographic disparities in the management of advanced lung cancer: a narrative review.Journal of thoracic disease · 2021Review
- The impact of treatment facility type on the survival of brain metastases patients regardless of the primary cancer type.BMC cancer · 2021Article
- Stereotactic radiosurgery combined with anlotinib for limited brain metastases with perilesional edema in non-small cell lung cancer: Rvision-001 study protocol.Thoracic cancer · 2020Article
- Intracranial Stereotactic Radiation Therapy With a Jawless Ring Gantry Linear Accelerator Equipped With New Dual Layer Multileaf Collimator.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRadiation treatment patterns in patients with brain metastases from non-small cell lung cancer (NSCLC) have not been well elucidated. The National Cancer Database (NCDB) was used to evaluate trends in the use of whole brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS) for brain metastasis from NSCLC.
methodsThis NCDB study included patients > 18 years old with metastatic NSCLC treated with single-fraction SRS or WBRT between 2004 and 2014. Chi-square, t-test, and multivariable logistic regression analyses were used to identify predictors of SRS versus WBRT.
resultsOf 40,803 patients, 34,183 (83.8%) received WBRT and 6,620 (16.2%) received SRS. SRS utilization increased from 7% (157 cases) in 2004 to 37% (1,346 cases) in 2014 (p < .001). SRS was utilized more by academic than community facilities (22% versus 13%, p < .001). The strongest independent predictors of SRS included year of diagnosis in 2010-2014 versus 2004-2009 (odds ratio [OR] 2.62, 95% CI 2.46-2.79, p < .0001), metropolitan versus rural (OR 2.26, CI 1.79-2.85, p < .0001), distance from cancer-reporting facility of ≥ 30 versus < 30 miles (OR 2.36, CI 2.18-2.56, p < .0001), private insurance versus non-insured patients (OR 1.96, CI 1.68-2.29, p < .0001), and academic versus community facility (OR 1.76, CI 1.66-1.87, p < .0001).
conclusionSRS for NSCLC brain metastases has steadily increased in the United States; however, WBRT remains the most commonly used. Wide geographic and socioeconomic variations exist in the utilization of SRS and WBRT for this patient population.
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