Evidence map›Paper›PMID 31011456›Full record

ArticleCase reports in hematology2019

A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings.

Morgan Bailey, Travis Maestas, Robert Betancourt, Dalia Mikhael, Hani M Babiker

Abstract readCase Reports
In one paragraph

Article in Case reports in hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Approach to Pancytopenia in a Deployed Service Member.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2022
    Article
  5. Fooled by the fragments: vitamin B12 deficiency masquerading as thrombotic thrombocytopenic purpura.Journal of community hospital internal medicine perspectives · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Morgan BaileyDepartment of Internal Medicine, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-9199-0171
Travis MaestasDepartment of Internal Medicine, University of Arizona, Tucson, AZ, USA.
Robert BetancourtDepartment of Internal Medicine, University of Arizona, Tucson, AZ, USA.
Dalia MikhaelDepartment of Internal Medicine, Banner University Medical Center-Tucson, Tucson, AZ, USA.
Hani M BabikerDepartment of Hematology-Oncology, University of Arizona Cancer Center, Tucson, AZ, USA.ORCID 0000-0002-9368-6296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombotic thrombocytopenia purpura (TTP) is a hematological emergency that requires rapid assessment followed by prompt initiation of therapy due to high mortality associated with delayed treatment. TTP has many causes including heritable syndromes, ADAMTS13 deficiency, and drugs-related etiologies. Profound vitamin B12 deficiency can, in rare cases, mimic TTP in presentation, and since plasmapheresis can be of limited benefit, prompt diagnosis is necessary for accurate treatment with B12. Therefore, careful analysis of all clinical signs, symptoms, and labs must be assessed. We report a patient who presented with a diagnosis of TTP, and repeat assessment confirmed a diagnosis of sever vitamin B12 (B12) deficiency with pancytopenia who was appropriately treated with B12.

Identifiers

PMID31011456
PMCPMC6442445

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.