ArticleIranian journal of pharmaceutical research : IJPR2018
Exercise During Adolescence Attenuated Depressive-Like Behaviors and Hippocampal Mitochondrial Dysfunction Following Early Life Stress in Adult Male Rats.
Article in Iranian journal of pharmaceutical research : IJPR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis.Pharmacological reports : PR · 2022Pooled it
- Relationship of immune-inflammatory pathway and stress-induced depression with neural regeneration.Neural regeneration research · 2026Article
- Nutritional interventions to counteract the detrimental consequences of early-life stress.Molecular psychiatry · 2025Review
- Mitochondria and early-life adversity.Mitochondrion · 2021Article
- Enhanced Neural Differentiation of Epidermal Neural Crest Stem Cell by Synergistic Effect of Lithium carbonate and Crocin on BDNF and GDNF Expression as Neurotrophic Factors.Iranian journal of pharmaceutical research : IJPR · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we assumed that treating animals with an antidepressant agents or voluntary running wheel exercise (RW) during adolescence may have beneficial outcomes against early life stress (ELS) which could be effective on behavior and mitochondrial function. Evidence indicated that ELS has deleterious impacts on brain and increases the risk of brain disorders such as depression. Maternal separation stress (MS) model to male rats (postnatal day or PND2-PND14) were performed to determination of depressive-like behaviors using the forced swimming test, splash test, and mitochondrial function in the hippocampus. Treating MS rats with both RW and fluoxetine (5 mg/kg/day, i.p) during adolescence (PND30-PND60) produced antidepressant-like effects in animals and attenuated the negative effects of ELS on hippocampal mitochondrial function in adult male rats. The results of the present study showed that (none) pharmacological treatments during adolescence are able to produce therapeutic effects against adverse effects of ELS on behavior and mitochondrial performance. These results showed the importance of adolescence as an important period of life and the long-lasting effects of ELS on hippocampal mitochondrial function which can suggest the possible contribution of abnormal mitochondrial function in pathogenesis of depression following experiencing ELS.
Indexed as
Identifiers
31011347PMC6447875W2924467731What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.