Evidence map›Paper›PMID 31011325›Full record

ArticleCase reports in oncology

Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: Case Series and Review of the Literature.

Nikhil Agrawal, Arjun Khunger, Pankit Vachhani, Teresa A Colvin, Alexander Hattoum, Edward Spangenthal, Anne B Curtis, Grace K Dy, Marc S Ernstoff, Igor Puzanov

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Article
  5. Article
  6. The role of tumor types in immune-related adverse events.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nikhil AgrawalDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences<bold></bold> at the University at Buffalo, Buffalo, New York, USA.
Arjun KhungerDepartment of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Pankit VachhaniDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Teresa A ColvinDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences<bold></bold> at the University at Buffalo, Buffalo, New York, USA.
Alexander HattoumDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences<bold></bold> at the University at Buffalo, Buffalo, New York, USA.
Edward SpangenthalDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Anne B CurtisDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences<bold></bold> at the University at Buffalo, Buffalo, New York, USA.
Grace K DyDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences<bold></bold> at the University at Buffalo, Buffalo, New York, USA.
Marc S ErnstoffDepartment of Medicine, Jacobs School of Medicine and Biomedical Sciences<bold></bold> at the University at Buffalo, Buffalo, New York, USA.
Igor PuzanovDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · USCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of patients with advanced stage cancers. However, immune-related adverse events are frequently observed. Cardiac toxicity from ICI therapy can range from asymptomatic troponin-I elevations to conduction abnormalities of the heart and even fulminant myocarditis. Although rare, myocarditis is a potentially fatal adverse effect of ICI therapy. We present a series of five cases of ICI-related cardio-toxicity diagnosed and managed at Roswell Park Comprehensive Cancer Center along with a review of published case reports in the literature. Our series highlights the importance of high clinical suspicion, early diagnosis of myocarditis, and prompt initiation of immunosuppressive therapy.

Indexed as

AutoimmuneCardio-oncologyCardiotoxicityImmune checkpoint inhibitorsMyocarditis

Identifiers

PMID31011325
PMCPMC6465686
OpenAlexW2924782035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.