ArticleMediators of inflammation2019
Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice.
Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04227873 (Sleep and Cognition After Ambulatory Hip and Knee Arthroplasty), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep and Cognition After Ambulatory Hip and Knee Arthroplasty
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Potential protein blood-based biomarkers for cognitive dysfunction in Parkinson's disease: a systematic review and network meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Effect of Dexmedetomidine on Postoperative Sleep Quality: A Systematic Review.Drug design, development and therapy · 2021Pooled it
- Effects of Intranasal Insulin Pretreatment on Preoperative Sleep Quality and Postoperative Delirium in Patients Undergoing Valve Replacement for Rheumatic Heart Disease.Nature and science of sleep · 2024Trial
- Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy.Drug design, development and therapy · 2023Trial
- [Effect of intraoperative dexmedetomidine on postoperative sleep disturbance in elderly surgical patients: a prospective multicenter cohort study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Observational
- Article
- Therapeutic Potential of Anesthesiology for Sleep Disorders in the Perioperative Period.Current neuropharmacology · 2026Review
- Esketamine ameliorates postoperative cognitive dysfunction aggravated by preoperative acute sleep deprivation in aged mice via the TLR4/NF-κB pathway.Frontiers in aging neuroscience · 2026Article
- Effect of opioid-free anesthesia on postoperative recovery in elderly patients undergoing laparoscopic abdominal surgery: a randomized controlled trial.Frontiers in medicine · 2026Article
- From Bench to Bedside: New Frontiers in Understanding and Treating Postoperative Delirium.Journal of clinical medicine · 2025Review
- Impact of isoflurane anesthesia on astrocyte connexin 30 expression in adult rats and its possible implications for postoperative neurocognitive disorder.European journal of medical research · 2025Article
- Preoperative Sleep Deprivation Exacerbates Anesthesia/Surgery-induced Abnormal GABAergic Neurotransmission and Neuronal Damage in the Hippocampus in Aged Mice.Molecular neurobiology · 2025Article
- Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances.Animal models and experimental medicine · 2025Article
- Association of heart rate variability with preoperative acute insomnia in patients scheduled for elective surgery.Frontiers in neurology · 2025Article
- Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNCommunications biology · 2024Article
- Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice.Neurochemical research · 2024Article
- Isoflurane anesthesia and sleep deprivation trigger delayed and selective sleep alterations.Scientific reports · 2024Article
- Article
- Sleep disorders cause Parkinson's disease or the reverse is true: Good GABA good night.CNS neuroscience & therapeutics · 2024Review
- The influence of sleep disorders on perioperative neurocognitive disorders among the elderly: A narrative review.Ibrain · 2024Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative cognitive dysfunction (POCD) is defined as new cognitive impairment (memory impairment and impaired performance) after surgery, especially in aged patients. Sleep disturbance is a common phenomenon before surgery that has been increasingly thought to affect patient recovery. However, little is known about the functional impact of preoperative sleep disturbance on POCD. Here, we showed that tibial fracture surgery induced cognitive deficit and production of proinflammatory cytokines interleukin-6 (IL-6) and IL-1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.