Evidence map›Paper›PMID 31011259›Full record

Observational studyWorld journal of gastroenterology2019

Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.

Yuichi Matsuno, Junji Umeno, Motohiro Esaki, Yoichiro Hirakawa, Yuta Fuyuno, Yasuharu Okamoto, Atsushi Hirano, Shigeyoshi Yasukawa, Fumihito Hirai, Toshiyuki Matsui and 12 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Translating IBD Genomics into Clinical Practice.Digestive diseases and sciences · 2026
    Review
  2. Article
  3. Article
  4. BiallelicFrontiers in endocrinology · 2026
    Article
  5. Article
  6. Article
  7. Pathogenesis of chronic enteropathy associated with theWorld journal of gastroenterology · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Age-related variations in prostaglandin E-major urinary metabolite values in Japanese children.Pediatrics international : official journal of the Japan Pediatric Society
    Article
  19. Chronic Enteropathy Associated withInflammatory intestinal diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 1 country.

Yuichi MatsunoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Junji UmenoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Motohiro EsakiDepartment of Endoscopic Diagnostics and Therapeutic, Saga University Hospital, Saga 849-8501, Japan.
Yoichiro HirakawaDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yuta FuyunoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yasuharu OkamotoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Atsushi HiranoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Shigeyoshi YasukawaDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino 818-8502, Japan.
Fumihito HiraiDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino 818-8502, Japan.
Toshiyuki MatsuiDepartment of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino 818-8502, Japan.
Shuhei HosomiDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545-8586, Japan.
Kenji WatanabeDepartment of Intestinal Inflammation Research, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.
Naoki HosoeCenter for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo 160-0016, Japan.
Haruhiko OgataCenter for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo 160-0016, Japan.
Tadakazu Hisamatsuthe Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka 181-8611, Japan.
Shunichi YanaiDivision of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Shuji KochiDivision of Gastroenterology, Matsuyama Red Cross Hospital, Matsuyama 790-8524, Japan.
Koichi KuraharaDivision of Gastroenterology, Matsuyama Red Cross Hospital, Matsuyama 790-8524, Japan.
Tsuneyoshi YaoDepartment of Gastroenterology, Sada Hospital, Fukuoka 810-0004, Japan.
Takehiro TorisuDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Takanari KitazonoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka 020-8505, Japan. tmatsumo@iwate-med.ac.jp.
Kyushu University · JPFukuoka University · JPKeio University · JPMatsuyama Red Cross Hospital · JPFukuoka Hospital · JPHyogo Medical University · JPIwate Medical University · JPOsaka City University · JPSaga University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with

aimTo examine whether prostaglandin E major urinary metabolites (PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.

methodsThis was a transactional study of 20 patients with CEAS and 98 patients with CD. CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of

resultsTwenty Japanese patients with CEAS and 98 patients with CD were enrolled. PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD (median 102.7

conclusionPGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.

Indexed as

AdultColonCrohn DiseaseDiagnosis, DifferentialFemaleHumansIleumIntestinal DiseasesMaleMiddle AgedMutationOrganic Anion TransportersProstaglandins EProstanoic AcidsUlcer11 alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acidOrganic Anion TransportersProstaglandins EProstanoic AcidsSLCO2A1 protein, humanChronic enteropathy associated with SLCO2A1 geneChronic nonspecific multiple ulcers of the small intestineCrohn’s diseaseProstaglandin E major urinary metabolitesSmall intestine

Identifiers

PMID31011259
PMCPMC6465938
OpenAlexW2937922438

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.