Evidence map›Paper›PMID 31011234›Full record

ArticleJournal of the American Statistical Association2018

Weighted False Discovery Rate Control in Large-Scale Multiple Testing.

Pallavi Basu, T Tony Cai, Kiranmoy Das, Wenguang Sun

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Null-free False Discovery Rate Control Using Decoy Permutations.Acta mathematicae applicatae Sinica (English series) · 2022
    Article
  8. Article
  9. Article
  10. Flexible and Fast Spatial Return Level Estimation Via a Spatially Fused Penalty.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2021
    Article
  11. Multiple comparison correction methods for whole-body magnetic resonance imaging.Journal of medical imaging (Bellingham, Wash.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pallavi BasuDepartment of Statistics and Operations Research, Tel Aviv University. Research supported in part by funding from the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement no[294519]-PSARPS.
T Tony CaiDepartment of Statistics, The Wharton School, University of Pennsylvania. The research of Tony Cai was supported in part by NSF Grant DMS-1403708 and NIH Grant R01 CA127334.
Kiranmoy DasInterdisciplinary Statistical Research Unit, Indian Statistical Institute, Kolkata.
Wenguang SunDepartment of Data Sciences and Operations, University of Southern California. The research of Wen-guang Sun was supported in part by NSF grant DMS-CAREER 1255406.

Funding

Methods for Integrative Genomic Data AnalysisR01GM129781 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Hongzhe Lee · 2018 to 2026
$3.5M
Methods for genomic data with graphical structuresR01CA127334 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LEE, HONGZHE · 2007 to 2016
$2.6M
NCI NIH HHS R01 CA127334NIGMS NIH HHS R01 GM129781
6 · The paper itself

Abstract

The use of weights provides an effective strategy to incorporate prior domain knowledge in large-scale inference. This paper studies weighted multiple testing in a decision-theoretic framework. We develop oracle and data-driven procedures that aim to maximize the expected number of true positives subject to a constraint on the weighted false discovery rate. The asymptotic validity and optimality of the proposed methods are established. The results demonstrate that incorporating informative domain knowledge enhances the interpretability of results and precision of inference. Simulation studies show that the proposed method controls the error rate at the nominal level, and the gain in power over existing methods is substantial in many settings. An application to a genome-wide association study is discussed.

Indexed as

Class weightsDecision weightsMultiple testing with groupsPrioritized subsetsValue to cost ratioWeighted p-value.

Identifiers

PMID31011234
PMCPMC6474384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.