ArticleNature chemistry2019
Practical and regioselective amination of arenes using alkyl amines.
Article in Nature chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Remote Desaturation of Unprotected Amines and C─H Amination of Alkanes by Polarity-Matched N-Radical Cations.Angewandte Chemie (International ed. in English) · 2026Article
- Photochemical, electrochemical and electrophotochemical C-N bond-forming cross-coupling reactions.Nature reviews. Chemistry · 2026Review
- Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides.Journal of peptide science : an official publication of the European Peptide Society · 2026Review
- Copper-Catalyzed Three-Component Selective 1,4-Amino Oxygenation of 1,3-Dienes.Angewandte Chemie (International ed. in English) · 2026Article
- Electrochemical oxidation enables aromatic C-H amination with dual mechanisms.Nature synthesis · 2026Article
- Metal-free para-selective C-H amination and azidation of N-arylhydroxylamines.Nature communications · 2025Article
- General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines.Nature communications · 2025Article
- Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day.Nature communications · 2024Article
- Electrochemical Non-Directed Arene C-H Amination.ChemCatChem · 2024Article
- Radical Polarity.Journal of the American Chemical Society · 2024Article
- Amination of Phenols and Halophenols via Pyridinium-Iridium Dual Photocatalysis.ACS catalysis · 2024Article
- Article
- Reductive Transamination of Pyridinium Salts to N-Aryl Piperidines.The Journal of organic chemistry · 2024Article
- Visible-Light Photocatalytic C-H Amination of Arenes Utilizing Acridine-Lewis Acid Complexes.Journal of the American Chemical Society · 2024Article
- Para-selective nitrobenzene amination lead by C(spNature communications · 2024Article
- Pushing Boundaries: What's Next in Metal-Free C-H Functionalization for Sulfenylation?Topics in current chemistry (Cham) · 2024Review
- Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines.Nature communications · 2024Article
- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- Ground State Generation and Cyclization of Aminium Radicals in the Formation of Tetrahydroquinolines.Organic letters · 2024Article
- Site-Selective Electrochemical Arene C-H Amination.Journal of the American Chemical Society · 2024Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of carbon-nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chemicals to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chemical syntheses in academia and industry. In general, these molecules are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C-H bond (that is, a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochemicals, peptides, chiral catalysts, polymers and organometallic complexes.
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31011173What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.