Evidence map›Paper›PMID 31010952›Full record

ArticleDiabetes care2019

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264.

Emily K Sims, Henry T Bahnson, Julius Nyalwidhe, Leena Haataja, Asa K Davis, Cate Speake, Linda A DiMeglio, Janice Blum, Margaret A Morris, Raghavendra G Mirmira and 12 more

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Emily K SimsDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN cevansmo@iu.edu eksims@iu.edu.ORCID 0000-0002-4393-954X
Henry T BahnsonDiabetes Clinical Research Program, Benaroya Research Institute, Seattle, WA.
Julius NyalwidheDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA.
Leena HaatajaDivision of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, MI.
Asa K DavisDiabetes Clinical Research Program, Benaroya Research Institute, Seattle, WA.
Cate SpeakeDiabetes Clinical Research Program, Benaroya Research Institute, Seattle, WA.
Linda A DiMeglioDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
Janice BlumDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN.
Margaret A MorrisDepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA.
Raghavendra G MirmiraDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0002-5013-6075
Jerry NadlerDepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA.
Teresa L MastracciDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.ORCID 0000-0003-1956-1951
Santica MarcovinaNorthwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, WA.
Wei-Jun QianBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA.
Lian YiBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA.
Adam C SwensenBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA.
Michele Yip-SchneiderDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN.
C Max SchmidtDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN.
Robert V ConsidineDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Peter ArvanDivision of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, MI.
Carla J GreenbaumDiabetes Clinical Research Program, Benaroya Research Institute, Seattle, WA.ORCID 0000-0003-4451-9800
Carmella Evans-MolinaCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN cevansmo@iu.edu eksims@iu.edu.ORCID 0000-0001-7764-8663

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Proinsulin Trafficking for Insulin BiosynthesisR01DK048280 · NIDDK · YESHIVA UNIVERSITY · PI ARVAN, PETER · 1994 to 2024
$10.5M
Transcriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5M
Validation of small molecule 12-lipoxygenase inhibitors in metabolic diseaseR01DK105588 · NIDDK · UNIVERSITY OF CHICAGO · PI KULKARNI, ROHIT N., MIRMIRA, RAGHAVENDRA G · 2015 to 2024
$5.5M
Mechanisms of Beta Cell Function in Health and DiseaseR01DK093954 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2011 to 2019
$3.5M
Biomarkers Of Beta Cell Stress In Type 1 Diabetes (BetaMarker)UC4DK104166 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EIZIRIK, DECIO LAKS, EVANS-MOLINA, CARMELLA · 2014 to 2014
$2.4M
Serum protein biomarkers for predicting type 1 diabetesDP3DK110844 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI QIAN, WEI-JUN · 2016 to 2016
$1.8M
Beta cell Derived miR-21 as an Intrinsic Protective Response and Biomarker in Type 1 DiabetesK08DK103983 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI SIMS, EMILY K · 2014 to 2018
$761k
BLRD VA I01 BX001733NIDDK NIH HHS DP3 DK110844NIDDK NIH HHS K08 DK103983NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK048280NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK093954NIDDK NIH HHS R01 DK105588NIDDK NIH HHS UC4 DK104166
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 1ProinsulinC-PeptideHumansInsulinC-PeptideInsulinProinsulin

Identifiers

PMID31010952
PMCPMC6489112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.