Evidence map›Paper›PMID 31010880›Full record

ReviewDiabetes2019

Function and Mechanism of Long Noncoding RNAs in Adipocyte Biology.

Lei Sun, Jiandie D Lin

Open access · bronzeAbstract readReview
In one paragraph

Review in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Pulling the trigger: Noncoding RNAs in white adipose tissue browning.Reviews in endocrine & metabolic disorders · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Long Non-Coding RNAs in the Pathogenesis of Diabetic Kidney Disease.Frontiers in cell and developmental biology · 2022
    Review
  20. Epigenetic modifications in diabetes.Metabolism: clinical and experimental · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Lei SunCardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore sun.lei@duke-nus.edu.sg jdlin@umich.edu.ORCID 0000-0003-3937-941X
Jiandie D LinLife Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, MI sun.lei@duke-nus.edu.sg jdlin@umich.edu.ORCID 0000-0001-8069-5647
Duke-NUS Medical School · SGUniversity of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Metabolic crosstalk through brown fat-enriched secreted factorsR01DK102456 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jiandie D Lin · 2015 to 2026
$4.9M
Glucose sensing by skeletal myocytesR01DK112800 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIN, JIANDIE D · 2017 to 2021
$1.9M
Endocrine regulation of metabolic health during agingR21AG055379 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIN, JIANDIE D · 2017 to 2018
$426k
NIA NIH HHS R21 AG055379NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK102456NIDDK NIH HHS R01 DK112800
6 · The paper itself

Abstract

The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel metabolism, adipocytes communicate with the immune system and other tissues by releasing diverse paracrine and endocrine factors to orchestrate adipose tissue remodeling and maintain systemic homeostasis. Significant progress has been made in delineating the regulatory networks that govern different aspects of adipocyte biology. Here we provide an overview on the emerging role of long noncoding RNAs (lncRNAs) in the regulation of adipocyte development and metabolism and discuss the implications of the RNA-protein regulatory interface in metabolic control.

Indexed as

AdipocytesAdipose TissueAnimalsHumansRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID31010880
PMCPMC6477904
OpenAlexW2937579997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.