Evidence map›Paper›PMID 31010860›Full record

ArticleAntimicrobial agents and chemotherapy2019

Advancing the Therapeutic Potential of Indoleamides for Tuberculosis.

Shichun Lun, Rokeya Tasneen, Tridib Chaira, Jozef Stec, Oluseye K Onajole, Tian J Yang, Christopher B Cooper, Khisi Mdluli, Paul J Converse, Eric L Nuermberger and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Thienopyrimidine amide analogs target MmpL3 inAntimicrobial agents and chemotherapy · 2025
    Article
  3. Article
  4. Article
  5. TheMicrobiology spectrum · 2024
    Article
  6. Molecular Mechanisms of MmpL3 Function and Inhibition.Microbial drug resistance (Larchmont, N.Y.) · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets.Frontiers in cellular and infection microbiology · 2021
    Review
  11. Review
  12. The Many Hosts of Mycobacteria 8 (MHM8): A conference report.Tuberculosis (Edinburgh, Scotland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Shichun LunCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rokeya TasneenCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tridib ChairaCenter for Drug Design Discovery and Development (C4D), SRM University, Delhi NCR, Sonepat, Haryana, India.
Jozef StecDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, Fullerton, California, USA.
Oluseye K OnajoleDepartment of Biological, Chemical and Physical Sciences, Roosevelt University, Chicago, Illinois, USA.
Tian J YangGlobal Alliance for TB Drug Development (TB Alliance), New York, New York, USA.
Christopher B CooperGlobal Alliance for TB Drug Development (TB Alliance), New York, New York, USA.
Khisi MdluliGlobal Alliance for TB Drug Development (TB Alliance), New York, New York, USA.
Paul J ConverseCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Eric L NuermbergerCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
V Samuel RajCenter for Drug Design Discovery and Development (C4D), SRM University, Delhi NCR, Sonepat, Haryana, India.
Alan KozikowskiStarWise Therapeutics LLC, University Research Park, Madison, Wisconsin, USA.
William R BishaiCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA wbishai1@jhmi.edu.
Johns Hopkins Medicine · USTB Alliance · USJohns Hopkins University · USSRM University · INMarshall B. Ketchum University · USRoosevelt University · US

Funding

Mycobacterium tuberculosis Survival Regulatory GenesR01AI037856 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 1997 to 2020
$7.2M
Aberrant immune activation in the tuberculosis granuloma: a pivotal role in necrosisR01HL133190 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BISHAI, WILLIAM RAMSES, KRAMNIK, IGOR · 2016 to 2019
$3.0M
NHLBI NIH HHS R01 HL133190NIAID NIH HHS R01 AI037856
6 · The paper itself

Abstract

Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of

Indexed as

Administration, OralAnimalsAntitubercular AgentsBiological AvailabilityDose-Response Relationship, DrugDrug Evaluation, PreclinicalFemaleIndolesMaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsMycobacterium tuberculosisTuberculosisAntitubercular AgentsIndoleschemotherapyindole-2-carboxamideMmpL3 inhibitormouse modelMycobacterium tuberculosismycolic acid

Identifiers

PMID31010860
PMCPMC6591635
OpenAlexW2936895705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.