Evidence map›Paper›PMID 31010857›Full record

ArticleAntimicrobial agents and chemotherapy2019

Bicarbonate Resensitization of Methicillin-Resistant

Selvi C Ersoy, Wessam Abdelhady, Liang Li, Henry F Chambers, Yan Q Xiong, Arnold S Bayer

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 34 citations in OpenAlex.

  1. Genomic investigation and clinical correlates of theAntimicrobial agents and chemotherapy · 2024
    Trial
  2. Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026
    Review
  3. An Achilles' heel for methicillin-resistantAntimicrobial agents and chemotherapy · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Phenotypic and genotypic correlates of the sodium bicarbonate-responsive phenotype among methicillin-resistant Staphylococcus aureus isolates from skin and soft-tissue infections.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2025
    Article
  9. Article
  10. Review
  11. Sensitizing methicillin-resistantAntimicrobial agents and chemotherapy · 2024
    Article
  12. Measuring beta-lactam minimum inhibitory concentrations inJournal of clinical microbiology · 2024
    Review
  13. Case report: Methicillin-resistantFrontiers in medicine · 2024
    Article
  14. Role of the NaHCOMicrobiology spectrum · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. The NaHCOAntimicrobial agents and chemotherapy · 2022
    Article
  19. Impacts of NaHCOAntibiotics (Basel, Switzerland) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Selvi C ErsoyLos Angeles Biomedical Research Institute, Torrance, California, USA.
Wessam AbdelhadyLos Angeles Biomedical Research Institute, Torrance, California, USA.
Liang LiLos Angeles Biomedical Research Institute, Torrance, California, USA.
Henry F ChambersDivision of Infectious Diseases, Zuckerberg San Francisco General Department of Medicine, San Francisco School of Medicine, University of California, San Francisco, California, USA.
Yan Q XiongLos Angeles Biomedical Research Institute, Torrance, California, USA yxiong@ucla.edu.
Arnold S BayerLos Angeles Biomedical Research Institute, Torrance, California, USA.
The Lundquist Institute · USUniversity of California, San Francisco · US

Funding

STREPTOCOCCAL PLATELET BINDING AND ENDOCARDITISR01AI041513 · NIAID · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI SULLAM, PAUL M. · 1997 to 2019
$5.6M
Novel Mechanisms of Beta-lactam Resistance in Staph AureusR01AI100291 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM, HENRY CHAMBERS, HENRY F · 2013 to 2023
$5.1M
Staphylococcal Adaptations to Platelet Microbicidal ProteinR01AI039108 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BAYER, ARNOLD S · 1997 to 2016
$5.1M
The role of purine biosynthesis and stringent response in persistent MRSA endovascular infectionsR01AI139244 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$2.2M
Bicarbonate-Mediated Enhancement of Beta-Lactam-MRSA Killing: Mechanisms and Clinical TranslatabilityR01AI146078 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$1.9M
Design and Development of Immunotolerant S. aureus BiotherapiesR42AI118133 · NIAID · LYTICON, LLC · PI BAILEY-KELLOGG, CHRIS, GRISWOLD, KARL E · 2017 to 2018
$1.5M
Novel Mechanisms of Beta-lactam Resistance in Staph AureusR56AI100291 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHATTERJEE, SOM, HENRY CHAMBERS, HENRY F · 2012 to 2017
$1.1M
NIAID NIH HHS R01 AI039108NIAID NIH HHS R01 AI041513NIAID NIH HHS R01 AI100291NIAID NIH HHS R01 AI139244NIAID NIH HHS R01 AI146078NIAID NIH HHS R42 AI118133NIAID NIH HHS R56 AI100291
6 · The paper itself

Abstract

Endovascular infections caused by methicillin-resistant

Indexed as

AnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial Proteinsbeta-LactamsBicarbonatesCathelicidinsCefazolinCulture MediaDrug SynergismEndocarditis, BacterialMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsOxacillinPenicillin-Binding ProteinsRabbitsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial Proteinsbeta-LactamsBicarbonatesCathelicidinsCefazolinCulture MediamecA protein, Staphylococcus aureusOxacillinPenicillin-Binding ProteinsSalicylic AcidSarA protein, Staphylococcus aureusantimicrobial susceptibility testinginfective endocarditisMRSApenicillin-binding proteinssodium bicarbonateβ-lactams

Identifiers

PMID31010857
PMCPMC6591647
OpenAlexW2953260231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.