ArticleJournal of immunology (Baltimore, Md. : 1950)2019
Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to
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Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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20 citing papers in PubMed, 31 citations in OpenAlex.
- Isolation of human satellite cells using CD29/CDH15 and a nanoparticle-based live Pax7 mRNA detection system, and their expansion with extracellular matrix and its derivatives.Stem cell research & therapy · 2026Article
- Invasive candidiasis.Nature reviews. Disease primers · 2024Review
- Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer.International journal of molecular sciences · 2024Article
- Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING.Nature microbiology · 2024Article
- Recombinant human KAI1/CD82 attenuates M1 macrophage polarization on LPS-stimulated RAW264.7 cells via blocking TLR4/JNK/NF-κB signal pathway.BMB reports · 2023Article
- Exploiting antifungal immunity in the clinical context.Seminars in immunology · 2023Review
- Transcriptomic analysis of pathways associated with ITGAV/alpha(v) integrin-dependent autophagy in human B cells.Autophagy · 2023Article
- The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan.mBio · 2023Article
- Pathogenesis and virulence ofVirulence · 2022Review
- Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America.Antibiotics (Basel, Switzerland) · 2022Review
- Dectin-1 Signaling Update: New Perspectives for Trained Immunity.Frontiers in immunology · 2022Review
- Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin andiScience · 2021Article
- The role of mycobiota-genotype association in inflammatory bowel diseases: a narrative review.Gut pathogens · 2021Review
- CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis.Investigative ophthalmology & visual science · 2021Article
- Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models.International journal of molecular sciences · 2021Review
- Role of Metastasis Suppressor KAI1/CD82 in Different Cancers.Journal of oncology · 2021Review
- Kangbainian Lotion Ameliorates Vulvovaginal Candidiasis in Mice by Inhibiting the Growth of Fluconazole-ResistantFrontiers in pharmacology · 2021Article
- The first line of defense: effector pathways of anti-fungal innate immunity.Current opinion in microbiology · 2020Review
- Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi.Frontiers in cellular and infection microbiology · 2020Review
- CD82 controls CpG-dependent TLR9 signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
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Authors and funding
25 authors at 7 institutions in 3 countries.
Jenny M TamDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Jennifer L ReedyDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Daniel P LukasonDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0003-1829-5735
Sunnie G KunaDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Mridu AcharyaImmunology Program, Benaroya Research Institute, Seattle, WA 98101.
Nida S KhanDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-5448-8289
Paige E NegoroDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Shuying XuDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Rebecca A WardDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0001-6752-5600
Michael B FeldmanDepartment of Medicine, Harvard Medical School, Boston, MA 02115.
Richard A DutkoDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Jane B JefferyDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Anna SokolovskaDepartment of Developmental Immunology, Massachusetts General Hospital, Boston, MA 02114.
Carl N WivaggDepartment of Medicine, Harvard Medical School, Boston, MA 02115.
Kara G LassenBroad Institute of Harvard and MIT, Cambridge, MA 02142.ORCID 0000-0001-7023-461X
François Le NaourInserm, Unité 1193, 94800 Villejuif, France.
Vasiliki MatzarakiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands.ORCID 0000-0002-5852-6801
Ethan C GarnerCenter for Systems Biology, Harvard University, Boston, MA 02115.ORCID 0000-0003-0141-3555
Ramnik J XavierDepartment of Medicine, Harvard Medical School, Boston, MA 02115.
Vinod KumarDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands.
Frank L van de VeerdonkDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands.
Cindy K MirantiDepartment of Cellular and Molecular Medicine, University of Arizona Health Sciences, Tucson, AZ 85724.
Michael K MansourDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Jatin M VyasDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114; jvyas@mgh.harvard.edu.ORCID 0000-0002-9985-9565
Massachusetts General Hospital · USHarvard University · USRadboud University Nijmegen · NLBroad Institute · USBenaroya Research InstituteInserm · FRUniversity of Arizona · US
Funding
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1MResearch Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6MHarvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5MFunctional characterization of CARD9 genetic variants in fungal immunityR01AI137325 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2018 to 2022
$3.5MThe Functional Role of the Tetraspanin CD82/Kai1 in Fungal Innate ImmunityR01AI136529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2018 to 2022
$2.7MFunctional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive ImmunityR01AI092084 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2011 to 2015
$2.2MThe role of TLR9 on Aspergillus fumigatus phagosomesR01AI097519 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2013 to 2016
$1.6MThe role of spleen tyrosine kinase (syk) in neutrophil responses to pathogenic fungi.R01AI132638 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2018 to 2021
$1.6MNCATS NIH HHS KL2 TR001100NHLBI NIH HHS T32 HL116275NIAID NIH HHS R01 AI092084NIAID NIH HHS R01 AI097519NIAID NIH HHS R01 AI132638NIAID NIH HHS R01 AI136529NIAID NIH HHS R01 AI137325NIAID NIH HHS T32 AI007061
Abstract
Tetraspanins are a family of proteins possessing four transmembrane domains that help in lateral organization of plasma membrane proteins. These proteins interact with each other as well as other receptors and signaling proteins, resulting in functional complexes called "tetraspanin microdomains." Tetraspanins, including CD82, play an essential role in the pathogenesis of fungal infections. Dectin-1, a receptor for the fungal cell wall carbohydrate β-1,3-glucan, is vital to host defense against fungal infections. The current study identifies a novel association between tetraspanin CD82 and Dectin-1 on the plasma membrane of
Indexed as
AnimalsCandida albicansCandidiasisCell LineCell MembraneDectin-1Genetic Predisposition to DiseaseHumansImmunity, CellularInterleukin-1betaKangai-1 ProteinLectins, C-TypeMacrophagesMembrane MicrodomainsMiceMice, Inbred C57BLDectin-1Interleukin-1betaKangai-1 ProteinLectins, C-TypeTumor Necrosis Factor-alpha
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.