Evidence map›Paper›PMID 31010851›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP.

Jennifer Goldblatt, Richard Ashley Lawrenson, Luke Muir, Saloni Dattani, Ashley Hoffland, Tomoko Tsuchiya, Shiro Kanegasaki, Shiranee Sriskandan, James E Pease

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. SpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. The N-terminal ELRThe Journal of biological chemistry · 2025
    Article
  5. Review
  6. Immunomodulating Enzymes fromMicroorganisms · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Role of extracellular matrix proteoglycans in immune cell recruitment.International journal of experimental pathology · 2022
    Review
  11. Review
  12. Review
  13. Structure, dynamics and immunogenicity of a catalytically inactive CComputational and structural biotechnology journal · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Jennifer GoldblattNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-2844-6261
Richard Ashley LawrensonDepartment of Medicine, Imperial College London, London W12 0NN, United Kingdom.
Luke MuirNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.
Saloni DattaniNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.
Ashley HofflandNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-2051-9363
Tomoko TsuchiyaResearch Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.ORCID 0000-0001-8677-8742
Shiro KanegasakiResearch Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.ORCID 0000-0001-7867-0109
Shiranee SriskandanDepartment of Medicine, Imperial College London, London W12 0NN, United Kingdom; j.pease@imperial.ac.uk s.sriskandan@imperial.ac.uk.ORCID 0000-0002-5214-4941
James E PeaseNational Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom; j.pease@imperial.ac.uk s.sriskandan@imperial.ac.uk.ORCID 0000-0003-3749-0341
Lung Institute · USImperial College London · GBNational Center for Global Health and Medicine · JP

Funding

Department of HealthWellcome TrustWellcome Trust 086721/Z/08/ZWellcome Trust 102126/Z/13/ZWellcome Trust WT091033MA
6 · The paper itself

Abstract

To evade the immune system, the lethal human pathogen

Indexed as

AnimalsCells, CulturedGlycosaminoglycansHeparinHumansInterleukin-8MiceNeutrophilsPeptide HydrolasesProtein BindingProtein EngineeringReceptors, Interleukin-8AReceptors, Interleukin-8BStreptococcal InfectionsStreptococcus pyogenesGlycosaminoglycansHeparinInterleukin-8Peptide HydrolasesReceptors, Interleukin-8AReceptors, Interleukin-8BSpyCEP protein, Streptococcus pyogenes

Identifiers

PMID31010851
PMCPMC6526389
OpenAlexW2940537135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.