Evidence map›Paper›PMID 31010828›Full record

ArticleThe Journal of biological chemistry2019

Elevated

Miranda Machacek, Harmony Saunders, Zhen Zhang, Ee Phie Tan, Jibiao Li, Tiangang Li, Maria T Villar, Antonio Artigues, Todd Lydic, Gentry Cork and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  7. Article
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  10. Article
  11. Review
  12. Frontiers in immunology · 2025
    Review
  13. Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Miranda MachacekFrom the Departments of Pathology and Laboratory Medicine.
Harmony SaundersFrom the Departments of Pathology and Laboratory Medicine.
Zhen ZhangBiochemistry and Molecular Biology, and.
Ee Phie TanBiochemistry and Molecular Biology, and.
Jibiao LiPharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 and.
Tiangang LiPharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 and.
Maria T VillarBiochemistry and Molecular Biology, and.
Antonio ArtiguesBiochemistry and Molecular Biology, and.
Todd Lydicthe Department of Physiology, Collaborative Mass Spectrometry Core, Michigan State University, East Lansing, Michigan 48824.ORCID 0000-0003-3830-7406
Gentry CorkFrom the Departments of Pathology and Laboratory Medicine.
Chad SlawsonBiochemistry and Molecular Biology, and cslawson@kumc.edu.ORCID 0000-0002-6886-4847
Patrick E FieldsFrom the Departments of Pathology and Laboratory Medicine, pfields@kumc.edu.
University of Kansas Medical Center · USHarefield Hospital · GBMichigan State University · USWarren Wilson College · US

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1M
University of Kansas Alzheimer's Disease Research Center (KU ADRC)P30AG072973 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JEFFREY Murray BURNS, RUSSELL H. SWERDLOW · 2021 to 2026
$25.3M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SWERDLOW, RUSSELL H. · 2011 to 2020
$16.6M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VIVIAN, JAY L · 2017 to 2021
$5.6M
Regulation of Bile Acid Metabolism and Signaling in Metabolic DiseasesR01DK117965 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Tiangang Li · 2019 to 2026
$2.7M
The role of hepatic Sortlin 1 in diabetic dyslipidemiaR01DK102487 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LI, TIANGANG · 2014 to 2018
$1.6M
The Role of the Histone Methyltransferase DOT1L in ErythropoiesisR01DK091277 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI FIELDS, PATRICK E · 2012 to 2016
$1.6M
NCI NIH HHS P30 CA168524NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG072973NIDDK NIH HHS R01 DK091277NIDDK NIH HHS R01 DK102487NIDDK NIH HHS R01 DK117965NIGMS NIH HHS P30 GM122731
6 · The paper itself

Abstract

Chronic, low-grade inflammation increases the risk for atherosclerosis, cancer, and autoimmunity in diseases such as obesity and diabetes. Levels of CD4

Indexed as

Acetyl-CoA CarboxylaseAcylationAdultAgedAged, 80 and overAnimalsCD4-Positive T-LymphocytesCytokinesFatty AcidsFemaleHumansInterleukin-17LipidomicsMaleMiceMice, Inbred C57BLACC1 protein, mouseAcetyl-CoA CarboxylaseCytokinesFatty AcidsInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Pyransthiamet GThiazolesacetyl-CoA carboxylase (ACC)inflammationlipid metabolismobesityO-linked N-acetylglucosamine (O-GlcNAc)RAR-related orphan receptor gamma t variantTh17T helper cellstype 2 diabetes

Identifiers

PMID31010828
PMCPMC6552434
OpenAlexW2941184981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.