Evidence map›Paper›PMID 31010817›Full record

ArticleInfection and immunity2019

Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles.

Luyao Yang, James N Higginbotham, Liping Liu, Gang Zhao, Sari A Acra, Richard M Peek, D Brent Polk, Hui Li, Fang Yan

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Postbiotics as Metabolites and Their Biotherapeutic Potential.International journal of molecular sciences · 2024
    Review
  6. Molecular Mechanisms ofMicroorganisms · 2024
    Review
  7. Article
  8. The Potential Therapeutic Role ofFoods (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Role of microbial secreted proteins in gut microbiota-host interactions.Frontiers in cellular and infection microbiology · 2022
    Review
  13. Review
  14. Extracellular membrane vesicles fromFrontiers in microbiology · 2022
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Luyao YangDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
James N HigginbothamDepartment of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Liping LiuDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Gang ZhaoDepartment of Gastrointestinal Cancer Biology, National Clinical Cancer Research Center, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Sari A AcraDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Richard M PeekDepartment of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
D Brent PolkDepartment of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Hui LiDepartment of Gastrointestinal Cancer Biology, National Clinical Cancer Research Center, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Fang YanDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA fang.yan@vumc.org.
Vanderbilt University Medical Center · USTianjin Medical University Cancer Institute and Hospital · CNChildren's Hospital of Los Angeles · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2009 to 2026
$27.5M
H.Pylori Relationship to Digestive Diseases and CancerR01CA077955 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2003 to 2026
$9.7M
Helicobacter Pylori and Gastrointestinal BiologyR01DK058587 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PEEK, RICHARD M. · 2001 to 2024
$7.8M
CYTOKINE REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONR01DK056008 · NIDDK · VANDERBILT UNIVERSITY · PI POLK, D BRENT · 1999 to 2020
$6.8M
Regulation of intestinal development by a Lactobacillus GG-derived proteinR01DK081134 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI YAN, FANG · 2009 to 2023
$4.7M
Stem Cell Dynamics in Colonic Epithelial RepairR01DK108648 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Cambrian Yangshao Liu, D Brent Polk · 2016 to 2026
$2.7M
REGULATION OF INTESTINAL EPITHELIAL CELL MIGRATIONR01DK054993 · NIDDK · VANDERBILT UNIVERSITY · PI POLK, D. BRENT · 2001 to 2005
$1.1M
NCI NIH HHS P01 CA116087NCI NIH HHS R01 CA077955NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK054993NIDDK NIH HHS R01 DK056008NIDDK NIH HHS R01 DK058587NIDDK NIH HHS R01 DK081134NIDDK NIH HHS R01 DK108648
6 · The paper itself

Abstract

The symbiotic relationship between the gut microbiome and the host provides a nutrient-rich environment for gut microbes and has beneficial effects on host health. Although the composition of the gut microbiome is known to be influenced by both host genetics and environmental factors, host effects on the activities and functions of the gut microbial communities remain poorly understood. Intestinal epithelial cells exert front-line responses to gut microbes and contribute to maintaining a healthy intestinal homeostasis. Here, seeking to elucidate whether intestinal epithelial cells modulate

Indexed as

AnimalsBacterial ProteinsEpithelial CellsHSP90 Heat-Shock ProteinsIntestinal MucosaLacticaseibacillus rhamnosusMiceMice, Inbred C57BLSecretory VesiclesBacterial ProteinsHSP90 Heat-Shock Proteinsp40 protein, Lactobacillus rhamnosuscolitisextracellular vesicleheat shock protein 90intestinal epithelial cellLactobacillus GGmicrobe-host interactionp40

Identifiers

PMID31010817
PMCPMC6589071
OpenAlexW2939873732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.